Results 61 to 70 of about 168,132 (304)

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Expression of L-ferritin and H-ferritin in ischemic brain.

, 2013
Rats were subjected to 60 min MCAO and 24 hour reperfusion. Contralateral and ipsilateral cerebral cortex (A,E), hippocampus (B,F) and corpus striatum (C,G) were isolated, homogenized, and analyzed for L- and H- ferritin by Western blotting ...
Ya-Shuo Zhao (343734), Yan-Zhong Chang (343738), Wen-Shuang Wu (343736), Hui Ding (308976), Shi-Yang Chang (343735), Xiang-Lin Duan (343739), Honglian Shi (339333), Cai-Zhen Yan (343731), Peng Yu (48605), Chen-Yang Zhao (343737)   +9 more
core   +1 more source

Chemistry and biology of ferritin

, 2021
International audienceAbstract Iron is an essential element required by cells and has been described as a key player in ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming multimeric assemblies with crystalline iron ...
Müller, Sebastian, Rodriguez, Raphaël, Plays, Marina   +2 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels [PDF]

, 2020
One approach to magnetogenetics uses radiofrequency (RF) waves to activate transient receptor potential channels (TRPV1 and TRPV4) that are coupled to cellular ferritins. The mechanisms underlying this effect are unclear and controversial.
Han, Victor, Shang, Trisha, Liu, Chunlei, Chen, Jingjia, Hernández-Morales, Miriam   +4 more
core   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Immunocytochemical localization of ferritin in the kidney and renal tumours

, 1987
The distribution of ferritin in the kidney and renal tumors was studied using a polyclonal anti-ferritin antiserum and immunocytochemical techniques. Ten fetal kidneys, 5 adult kidneys and 56 renal tumours were studied.
Fleming, S., S. Fleming
core   +2 more sources

Relationship between Hb and ferritin levels among the patient groups, as stratified by serum ferritin levels.

, 2016
A significant correlation was found between Hb and ferritin levels only in patients with ferritin levels
Toshiaki Murata (2550085), Toru Inoue (1877344), Takahiro Kuragano (2550079), Shouichi Fujimoto (636723), Osamu Matsumura (2550082), Nobuhiko Joki (2550076), Takeshi Nakanishi (515936), Atushi Fukatsu (2550088), Hideyasu Kiyomoto (797139), Hiroki Hase (2550097), Yukihiro Itakura (2550073), Akihiko Matsuda (2550094), Taiga Hara (2550091), Kenichiro Kitamura (191544)   +13 more
core   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source