Results 71 to 80 of about 637 (207)
Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin +17 morewiley +1 more sourceA Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair
Advanced Science, EarlyView.We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu +7 morewiley +1 more sourceTargeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer
Advanced Science, EarlyView.A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong +15 morewiley +1 more sourceComputation‐Guided Tunnel Engineering Enhances O2 Transport and H2O2 Resistance of Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenases
Advanced Science, EarlyView.This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.Huan Liu, Lunjie Wu, Liying Mao, Songyin Zhao, Hu Liu, Shiyi Xin, Donglin Zhao, Jie Gu, Yan Xu, Xinye Wang, Yao Nie +10 morewiley +1 more sourceThe effect of change in pH on the solubility 01 iron bis-glycinate chelate and other iron compounds</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Archivos Latinoamericanos de Nutrición</i>, 2001 </span><br><span class="r_content">Efecto de cambios de pH sobre la solubilidad del hierro bis-glicinato quelado y de otros compuestos de hierro. Se estudió el efecto del cambio de pH de 2 a 6 sobre la solubilidad del hierro de sulfato ferroso, fumarato ferroso, hierro bis-glicinato ...</span><br><span class="r_sub"><i>María Nieves García-Casal<span id="ma_9" style="display:none">, Miguel Layrisse</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+1 more</a></small></i></span><br><small><a href="https://doaj.org/article/72e98853eb7c41378c90417caaa007f9" target="_blank" rel="nofollow" title="doaj.org/article/72e98853eb7c41378c90417caaa007f9">doaj</a> </small> <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3390/jmmp8030111" target="_blank" rel="nofollow">Green Innovation Practices: A Case Study in a Foundry</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Journal of Manufacturing and Materials Processing</i></span><br><span class="r_content">The foundry industry is responsible for the production of several potentially polluting and hazardous compounds. One of the major sources of pollution is the use of organic binders for the manufacturing of sand cores and sand moulds.</span><br><span class="r_sub"><i>Gianluca Fratta<span id="ma_10" style="display:none">, Ivan Stefani, Sara Tapola, Stefano Saetta</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+3 more</a></small></i></span><br><small><a href="https://doaj.org/article/5ade9d60f2a24bc3b7afa6256e648cc6" target="_blank" rel="nofollow" title="doaj.org/article/5ade9d60f2a24bc3b7afa6256e648cc6">doaj</a> </small> <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.3390%2Fjmmp8030111" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3390/jmmp8030111'); alert('Copied the doi');">copy doi</a> <small>(10.3390/jmmp8030111)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-iron/" class="suggestion"onclick="show_loader();"><b>iron</b></a><br/><a href="/q-3._good_health/" class="suggestion"onclick="show_loader();"><b>3. good health</b></a><br/><a href="/q-anemia/" class="suggestion"onclick="show_loader();"><b>anemia</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-7._clean_energy/" class="suggestion"onclick="show_loader();"><b>7. clean energy</b></a><br/><a href="/q-humans/" class="suggestion"onclick="show_loader();"><b>humans</b></a><br/><a href="/q-6._clean_water/" class="suggestion"onclick="show_loader();"><b>6. clean water</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-weight_loss/" class="suggestion"onclick="show_loader();"><b>weight loss</b></a><br/><a href="/q-ferric_compounds/" class="suggestion"onclick="show_loader();"><b>ferric compounds</b></a><br/><a href="/q-chemistry/" class="suggestion"onclick="show_loader();"><b>chemistry</b></a><br/></div></div></div><div class="pagenav"><a href="/q-ferrous_compounds/p-7/" rel="nofollow"><b>previous</b></a> <a href="/q-ferrous_compounds/p-6/" rel="nofollow">6</a> <a href="/q-ferrous_compounds/p-7/" rel="nofollow">7</a> <b>8</b> <a href="/q-ferrous_compounds/p-9/" rel="nofollow">9</a> <a href="/q-ferrous_compounds/p-10/" rel="nofollow">10</a> <a href="/q-ferrous_compounds/p-9/" id="next" rel="nofollow"><b>next</b></a> </div><br></div>
</div>
<script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px">
<a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a>
</div></div>
<link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/>
<script> (function(ss,ex){ window.ldfdr=window.ldfdr||function(){(ldfdr._q=ldfdr._q||[]).push([].slice.call(arguments));}; (function(d,s){ fs=d.getElementsByTagName(s)[0]; function ce(src){ var cs=d.createElement(s); cs.src=src; cs.async=1; fs.parentNode.insertBefore(cs,fs); }; ce('https://sc.lfeeder.com/lftracker_v1_'+ss+(ex?'_'+ex:'')+'.js'); })(document,'script'); })('JMvZ8gvrWA9a2pOd'); </script>
</body>
</html>
