Results 121 to 130 of about 383,345 (315)

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

open access: yesAdvanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li   +22 more
wiley   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

open access: yesAdvanced Science, EarlyView.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao   +7 more
wiley   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

open access: yesAdvanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai   +15 more
wiley   +1 more source

Enhancing Binding by Electron Transfer at Heterointerfaces of Biochar‐Modified Hydrogel to Improve Utilization Efficiency of Wastewater Recovered Nutrients

open access: yesAdvanced Science, EarlyView.
Enhancing the utilization efficiency of nutrients recovered from wastewater is achieved through hydrogel modification by biochar. The strategy improves nutrient binding to hydrogels via electron transfer at heterointerfaces, thereby reducing nutrient release rate.
Hao Hu   +7 more
wiley   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

open access: yesAdvanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao   +14 more
wiley   +1 more source

Hidden Charge‐Order in the Mixed‐Valent K0.75Li2Cr6O12 High‐Pressure Oxide

open access: yesAdvanced Science, EarlyView.
K0.75Li2Cr6O12 is one of the few mixed valent chromium oxides. It shows a single angle spiral magnetic structure with a k = [1/3 1/3 ¼] propagation vector. Density functional theory reveals a hidden charge order that is necessary to stabilize the antiferromagnetic (AFM) ground state.
Angel M. Arévalo‐López   +3 more
wiley   +1 more source

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