Results 131 to 140 of about 1,176,085 (362)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

open access: yesAdvanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim   +6 more
wiley   +1 more source

The Fertility Pattern of Twins and the General Population Compared: Evidence from Danish Cohorts 1945-64 [PDF]

open access: yes
Twin studies provide an important possibility for demographers to analyze patterns of heritability and to estimate structural models with controls for endowments. These possibilities are increasingly used in the context of fertility and related behaviors.
Axel Skytthe   +3 more
core  

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

open access: yesAdvanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li   +9 more
wiley   +1 more source

Reproductive behaviour of migrant women in Germany: Data, patterns and determinants [PDF]

open access: yes
This paper examines the fertility of female migrants in Germany. After introducing major hypotheses on migrant fertility we give an overview on German datasets that are available for migrant fertility research.
Martin Kohls, Susanne Schmid
core   +1 more source

Dissemination and adoption of bottom-up agriculture to improve soil fertility in Africa: An interdisciplinary approach [PDF]

open access: yes, 2018
Soil fertility is at stake at a global scale, putting pressure on food security, poverty alleviation and environmental protection, under scenarios of climate change that in most cases aggravate the threat. In sub-Saharan Africa, a combination of depleted
Adamtey, Noah   +4 more
core  

AAV‐mediated gene therapy restores natural fertility and improves physical function in the Lhcgr‐deficient mouse model of Leydig cell failure [PDF]

open access: gold
Suyuan Zhang   +18 more
openalex   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

open access: yesAdvanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi   +10 more
wiley   +1 more source

Malthus to Modernity: England’s First Fertility Transition, 1760-1800 [PDF]

open access: yes
English fertility history is generally regarded as having been composed of two re-gimes: an era of unregulated marital fertility, from at least 1540 to 1890, then the modern era, with regulated marital fertility, lower for higher social classes.
Clark, Gregory, Cummins, Neil
core   +1 more source

Perspectives of Obstetricians and Gynaecologists on the Use of Weight Loss Medications

open access: yesReproductive, Female and Child Health
Objectives To investigate perspectives of Obstetricians and Gynaecologists on the use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) for weight loss in women living with obesity and subfertility. Methods Qualified Obstetricians and Gynaecologists
Ciara Nolan   +4 more
doaj   +1 more source

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