Results 21 to 30 of about 302,375 (263)

Does body mass index impact assisted reproductive technology treatment outcomes in gestational carriers

Reproductive Biology and Endocrinology, 2020
Background The purpose of this study was to assess whether increased body mass index (BMI) negatively affects assisted reproductive technology (ART) outcomes among gestational carriers.
Noga Fuchs Weizman, Miranda K. Defer, Janice Montbriand, Julia M. Pasquale, Adina Silver, Clifford L. Librach   +5 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

pHantastic Embryos and Where to Find Them: Can a Real-Time pH Monitoring System Represent the pH Environment of Culture Media?

Fertility & Reproduction, 2022
Background: Maintaining optimal pH of culture media reduces environmental stressors on gametes and embryos, which has been shown to be critical in supporting embryo development.
Casey DEAN, Kavyadharshini GUNASEGARAN, Justine GABRIEL, Daniela IACOBELLI, Kelli SORBY   +4 more
doaj   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak, Rebecca Williamson‐Lewis, Michael O'Connor, Michael Palgon, Yu‐Ra Kim, Michael Schuckenbrock, Paula Edwards, Abraham Mendoza, Anthony Adams, Brian Arriaga‐Solis, Justin Parker, Harry Tinoco‐Giraldo, Jason King, C. Michael Fordis, Karen E. Effinger, Maria Monica Gramatges   +15 more
wiley   +1 more source

Investigation into Platelet Rich Plasma (PRP) Infusions Within the Intrauterine Cavity, to Support the Development of Endometrial Lining in Transfer Cycle Patients

Fertility & Reproduction, 2022
Background: Poor endometrial lining is classically referenced as
Jenyne ALCOCK, Dr Lynn BURMEISTER, Shelley ZHANG, Eve GLAGE, Kelli SORBY   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Embryo utilisation rate and transferable embryo to oocyte ratio correlate positively with livebirth rate but negatively with oocyte number: analysis of 14,156 fresh IVF/ICSI cycles

Journal of Ovarian Research
Background The live birth rates (LBRs) do not rise after a certain number of oocytes are collected in fresh IVF cycles. Although the detrimental effect of high ovarian response on the endometrium has been recognised, the effect of high oocyte yield on ...
Adrija Kumar Datta, Geeta Nargund, Martin Wilding, Sam Dobson, Stuart Campbell   +4 more
doaj   +1 more source

The Complexity Around Mosaic Embryo Decision Making– A Genetic Counselling Perspective

Fertility & Reproduction, 2022
Background: In recent years there is an evident increase in the interest of transferring mosaic embryos. Our genetic counselling team have reported mosaic results to over 250 patients since the beginning of 2020, and there is an upward trend in patient ...
Maddie TEED, Abbie JEDWAB, Chloe STUTTERD, Kelli SORBY, Alice WEEKS   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Understanding the impact of lifestyle and demographic factors on DNA fragmentation index (DFI) among infertile men

BMC Urology
Background Sperm DNA fragmentation detection methods include SCSA, SCD, COMET assay, and TUNEL. In 2021, the DFI test became the first evidence-based sperm DNA integrity test included in international guidelines. However, limited data exists from Nigeria.
Abayomi Bolaji Ajayi, Victor Ajayi, Kazeem Adewale Osuolale, Ngozi Obi, Roselyn Obasa-Gbadebo, Toluwanimi Balogun, Anuoluwa Alaka, Olaoluwa Musa, Edith Omokhegbele   +8 more
doaj   +1 more source