Results 41 to 50 of about 587,238 (307)

The Complexity Around Mosaic Embryo Decision Making– A Genetic Counselling Perspective

Fertility & Reproduction, 2022
Background: In recent years there is an evident increase in the interest of transferring mosaic embryos. Our genetic counselling team have reported mosaic results to over 250 patients since the beginning of 2020, and there is an upward trend in patient ...
Maddie TEED, Abbie JEDWAB, Chloe STUTTERD, Kelli SORBY, Alice WEEKS   +4 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Understanding the impact of lifestyle and demographic factors on DNA fragmentation index (DFI) among infertile men

BMC Urology
Background Sperm DNA fragmentation detection methods include SCSA, SCD, COMET assay, and TUNEL. In 2021, the DFI test became the first evidence-based sperm DNA integrity test included in international guidelines. However, limited data exists from Nigeria.
Abayomi Bolaji Ajayi, Victor Ajayi, Kazeem Adewale Osuolale, Ngozi Obi, Roselyn Obasa-Gbadebo, Toluwanimi Balogun, Anuoluwa Alaka, Olaoluwa Musa, Edith Omokhegbele   +8 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

#63 : Clinical Prognosis of Human Blastocysts Showing Spontaneous Collapsing: A Systematic Review and Meta-Analysis

Fertility & Reproduction, 2023
Background and Aims: Spontaneous collapsing (SC) is a relatively new viability biomarker of human blastocysts which is only detectable via time-lapse videography.
Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu   +5 more
doaj   +1 more source

Fertilization 2: Polyspermic Fertilization [PDF]

, 2017
During fertilization in animals, a haploid egg nucleus fuses with a haploid sperm nucleus to restore the diploid genome. In most animals including mammals, echinoderms, and teleostei, the penetration of only one sperm into an egg is ensured at fertilization because the entry of two or more sperm is prevented by polyspermy block systems in these eggs ...
openaire   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Value-based healthcare in fertility care using relevant outcome measures for the full cycle of care leading towards shared decision-making: a retrospective cohort study

BMJ Open, 2023
Objective To determine if the introduction of value-based healthcare (VBHC) in fertility care can help to create realistic expectations in patients resulting in increased patient value, by demonstrating the relevance of defining outcome measures that ...
Milou Bensink, Joy Volkerink, Gijs Teklenburg, Casandra C A W van Bavel, Walter K H Kuchenbecker, Ben J Cohlen, Max H J M Curfs   +6 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay

Stem Cell Research & Therapy, 2017
Background Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs).
Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher, Clifford L. Librach   +4 more
doaj   +1 more source