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Fertility Preservation [PDF]

open access: yesMayo Clinic Proceedings, 2011
Of the estimated 1.5 million men and women who were diagnosed as having cancer in 2010, approximately 10% are younger than 45 years. For these individuals, cancer treatment can be lifesaving but can permanently affect reproductive capacity. The American Society of Clinical Oncology has recommended that oncologists discuss the possibility of infertility
Jani R, Jensen   +2 more
openaire   +4 more sources

Human Sperm Morphology as a Marker of Its Nuclear Quality and Epigenetic Pattern

open access: yesCells, 2022
Background: Human sperm chromatin condensation is a sum of epigenetic events that allows for the near-complete replacement of histones with protamines.
Marion Bendayan   +6 more
doaj   +1 more source

The Late Effects of Cancer Treatment on Female Fertility and the Current Status of Fertility Preservation—A Narrative Review

open access: yesLife, 2023
Fertility counseling should be offered to all individuals of young reproductive age early in the patient’s trajectory following a cancer diagnosis. Systemic cancer treatment and radiotherapy often have an inherent gonadotoxic effect with the potential to
Kenny A. Rodriguez-Wallberg   +3 more
doaj   +1 more source

Is letrozole during ovarian stimulation useful in breast cancer patients undergoing fertility preservation to reduce early luteal progesterone levels following GnRH-agonist trigger?

open access: yesReproductive Biology and Endocrinology, 2022
Background In absence of contraindication, breast cancer patients of reproductive age can undergo fertility preservation with controlled ovarian stimulation for oocyte/embryo cryopreservation before the administration of potentially gonadotoxic ...
Imane Lalami   +8 more
doaj   +1 more source

[Fertility preservation].

open access: yesUgeskrift for laeger, 2021
Fertility preservation should be considered in girls and young women faced with a potentially gonadotoxic treatment such as chemotherapy. IVF can be performed with the aim to collect and freeze the oocytes, or ovarian tissue can be cryopreserved and transplanted back to the patient at a later stage.
Colmorn, Lotte Berdiin   +3 more
openaire   +5 more sources

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model

open access: yesJournal of Ovarian Research, 2023
Background Premature ovarian failure (POF) is one of the leading causes of female infertility and is accompanied by abnormal endocrine, seriously affecting female quality of life.
Wenjie Dai   +11 more
doaj   +1 more source

Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis

open access: yesFrontiers in Endocrinology, 2023
Background and objectivePCOS is a common metabolic disorder in women of reproductive age, which pathogenesis is very complex. The role of ferroptosis in PCOS is a novel finding, and the mechanistic studies are not clear. Metformin is a commonly used drug
Qingjie Peng   +17 more
doaj   +1 more source

High-Survival Rate After Microinjection of Mouse Oocytes and Early Embryos With mRNA by Combining a Tip Pipette and Piezoelectric-Assisted Micromanipulator

open access: yesFrontiers in Cell and Developmental Biology, 2021
Utilizing microinjection to introduce biological molecules such as DNA, mRNA, siRNA, and proteins into the cell is well established to study oocyte maturation and early embryo development in vitro. However, microinjection is an empirical technology.
Lei-Ning Chen   +18 more
doaj   +1 more source

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