Results 131 to 140 of about 481,788 (339)

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Soil microbiome dysbiosis and rhizosphere metabolic dysfunction drive continuous cropping obstacles of Codonopsis tangshen

Frontiers in Microbiology
Successive monocropping of Codonopsis tangshen causes continuous cropping obstacles, impairing growth, yield, and quality. To investigate the soil environmental and microbial changes caused by these obstacles, we collected both continuous cropping (C ...
Dabing Xu, Chenglin Peng, Guohan Si, Xiangyu Xu, Shujun Zhao, Chuan You, Wuxian Zhou   +6 more
doaj   +1 more source

Socio-economic Factors Influencing Adoption of Fertilizer for Maize Production in Nepal: A Cast Study of Chitwan District [PDF]

Soil fertility is considered as the most important constraint to increase maize production in Nepal. Although farmers generally apply farmyard manure available on their farms, there is increasing trend towards the use of fertilizers that is likely to ...
Matsuoka, Atsushi, Paudel, Pashupati, Shrestha, Arjun Kumar   +2 more
core   +1 more source

Greenhouse gas emissions of regionally produced alternative feedstuffs rich in protein for Austrian dairy production [PDF]

, 2010
The aim of this study was to analyse the potential greenhouse gas emissions (GHGE) of locally and regionally produced, alternative protein‐rich feedstuffs (APRFs) which can be utilised in dairy cattle feeding as compared to extracted soybean meal (SBME ...
Hörtenhuber, Stefan, Zollitsch, Werner
core  

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

Advanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana, Ryan Sentosa, Caterina Sturtzel, Martin Pfister, René Werkmeister, Anna Schmitt, David Traver, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber   +10 more
wiley   +1 more source

Ashes for organic farming [PDF]

, 2013
Nowadays only eight percent of the cultivated field area is used for organic farming. The Ministry of Agriculture and Forestry has published the guidelines for the program of organic farming to diversify the supply and the consumption of organic food ...
Heinonen, M., Kousa, T., Peltonen, K., Suoniitty, T.   +3 more
core  

EVALUATION AND CALIBRATION OF PHOSPHORUS SOIL TEST METHODS FOR PREDICTING FERTILIZER REQUIREMENTS OF POTATOES [PDF]

, 1957
J. A. Smith, R. W. Sheard
openalex   +1 more source

Systematic Targeting of GD2‐Positive Neuroblastoma Tumors With a Photooncolytic Phage Nanovector Platform

Advanced Science, EarlyView.
A tumor‐penetrating photooncolytic phage is developed for selectively targeting and delivering photosensitizers to GD2‐positive Neuroblastoma cells. Upon light activation, it precisely induces oncolysis of GD2‐positive cells with no effect on GD2‐negative ones.
Suleman Khan Zadran, Nicola Facchinello, Piergiuseppe De Rosa, Roberto Saporetti, Paolo Emidio Costantini, Luca Ulfo, Michela Nigro, Annapaola Petrosino, Lucia Pappagallo, Sara Aloisi, Giorgio Milazzo, Zainul Abe Din, Alberto Rigamonti, Leonardo Flora, Martina Santulli, Leonardo Cimadom, Giampaolo Zuccheri, Mattia Zangoli, Manuele Di Sante, Matteo Di Giosia, Francesca Di Maria, Roberto Bernardoni, Eveline Barbieri, Matteo Calvaresi, Alberto Danielli, Giovanni Perini   +25 more
wiley   +1 more source

Effect of plant-derived microbial soil legacy in a grafting system—a turn for the better

Microbiome
Background Plant-soil feedback arises from microbial legacies left by plants in the soil. Grafting is a common technique used to prevent yield declines in monocultures.
Tingting Wang, Yang Ruan, Qicheng Xu, Qirong Shen, Ning Ling, Philippe Vandenkoornhuyse   +5 more
doaj   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source