Results 51 to 60 of about 112,777 (291)

DSM-5 criteria for substance use disorders: recommendations and rationale. [PDF]

, 2013
Since DSM-IV was published in 1994, its approach to substance use disorders has come under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but concerns have also arisen.
Auriacombe, Marc, Borges, Guilherme, Bucholz, Kathleen, Budney, Alan, Compton, Wilson M, Crowley, Thomas, Grant, Bridget F, Hasin, Deborah S, Ling, Walter, O'Brien, Charles P, Petry, Nancy M, Schuckit, Marc   +11 more
core   +1 more source

Against the impairment argument: A reply to Hendricks [PDF]

, 2020
In an article of this journal, Perry Hendricks makes a novel argument for the immorality of abortion. According to his impairment argument, abortion is immoral because: (a) it is wrong to impair a fetus to the nth degree, such as causing the fetus to ...
Räsänen, Joona
core   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Organ of vision in children with fetal alcohol spectrum disorders

Klinika Oczna
Fetal alcohol spectrum disorders (FASD) are a group of permanent birth defects resulting from maternal alcohol consumption during pregnancy, characterized by neurological, somatic, and mental abnormalities.
Mirosława Grałek, Anna Niwald, Katarzyna Piasecka, Anna Krzymianowska, Ewa Lipiec   +4 more
doaj   +1 more source

Results of criterional and descriptive assessing dysmorphological disorders associated with prenatal exposure to ethanol in children 7-10 years of age

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
Diagnosis of disorders that determine the clinical manifestations of fetal alcohol syndrome (FAS) can cause certain difficulties: children with intrauterine alcohol exposure have a fairly wide range of physical, cognitive and behavioral features.
E. V. Fadeeva, A. Yu. Nenastieva, G. А. Korchagina   +2 more
doaj   +1 more source

BUSM News and Notes [PDF]

, 1992
Monthly newsletter providing updates of interest to the Boston University School of Medicine ...
Boston University School of Medicine Office of Informational Services
core  

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Educators’ relational experiences with learners identified with fetal alcohol spectrum disorder

South African Journal of Education, 2017
Between 2009 and 2011 a prevalence study on Fetal Alcohol Spectrum Disorder (FASD) was conducted in a rural area of the Western Cape in South Africa by Prof.
Izanette Van Schalkwyk , Sandra Marais
doaj   +1 more source

Polymicrogyria in Fetal Alcohol Syndrome

Neuropediatrics, 2009
AbstractBACKGROUND: Intrauterine exposure to alcohol may result in a distinct pattern of craniofacial abnormalities and central nervous system dysfunction, designated fetal alcohol syndrome (FAS). The spectrum of malformations of the brain associated with maternal alcohol abuse during pregnancy is much broader than the relatively uniform clinical ...
Reinhardt, Konstanze, Mohr, Alexander, Gärtner, Jutta, Spohr, Hans-Ludwig, Brockmann, Knut   +4 more
openaire   +3 more sources

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source