Distance to healthy cardiovascular dynamics from fetal heart rate scale-dependent features in pregnant sheep model of human labor predicts cardiovascular decompensation [PDF]
The overarching goal of the present work is to contribute to the understanding of the relations between fetal heart rate (FHR) temporal dynamics and the well-being of the fetus, notably in terms of predicting cardiovascular decompensation (CVD).
arxiv +1 more source
Acute resveratrol exposure does not impact hemodynamics of the fetal sheep
Babies born growth restricted are at an increased risk of both poor short‐and long‐term outcomes. Current interventions to improve fetal growth are ineffective and do not lower the lifetime risk of poor health status. Maternal resveratrol (RSV) treatment
Jack R. T. Darby+9 more
doaj +1 more source
Shape-aware Segmentation of the Placenta in BOLD Fetal MRI Time Series [PDF]
Blood oxygen level dependent (BOLD) MRI time series with maternal hyperoxia can assess placental oxygenation and function. Measuring precise BOLD changes in the placenta requires accurate temporal placental segmentation and is confounded by fetal and maternal motion, contractions, and hyperoxia-induced intensity changes.
arxiv +1 more source
Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A
Microfluidic technology enables recapitulation of organ-level physiology to answer pertinent questions regarding biological systems that otherwise would remain unanswered.
Brady Trevisan+13 more
doaj +1 more source
Despite the rapid advances in fetal medicine and pediatric surgery, congenital chylothoraces have an associated mortality of 22–65% and an increased morbidity resulting from pulmonary hypoplasia, severe infections secondary to immune globulin ...
Maggie M. Hodges+7 more
doaj +1 more source
Are we ready for widespread implementation of lactate POCT in fetal blood sampling? An analytical and clinical verification of the novel statstrip POCT analyzer. [PDF]
Objectives: Currently, pH values are used in fetal scalp blood sampling as a parameter to rule out fetal distress during the delivery. Due to a high number of pre-analytical errors in pH measurements, lactate measurement is already extensively examined ...
Spronk N+2 more
europepmc +2 more sources
Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel+21 more
core +2 more sources
Fetal Blood Volume and Fetal Placental Blood Flow in Lambs
SummaryIn the conscious, nonmedicated sheep fetus, blood volume strongly influences placental blood flow, a change of 1% in volume being associated with a change of 1.7 ± 0.1% in flow. This relationship is valid between blood volumes of 80 to 110% of normal, is independent of time over a period of several days and independent of concomitant changes in ...
Charles F. Gault+3 more
openaire +3 more sources
An exploration of the potential utility of fetal cardiovascular MRI as an adjunct to fetal echocardiography [PDF]
Objectives: Fetal cardiovascular magnetic resonance imaging (MRI) offers a potential alternative to echocardiography, although in practice, its use has been limited. We sought to explore the need for additional imaging in a tertiary fetal cardiology unit
Al Nafisi+42 more
core +3 more sources
Fetal oxygen delivery and consumption and blood gases in relation to gestational age [PDF]
Fetal oxygen delivery and consumption and blood gases in relation to gestational age. Oxygen crosses the placenta by diffusion and placental permeability to O$_2$ is high. Thus, the fetus receives adequate amounts, but vascular Po$_2$ is much lower than after birth. Studies of sustained fetal hypoxemia and acute 40-45% hemorrhage show that hypoxemia is
arxiv