Results 71 to 80 of about 5,347,455 (382)
Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A
Frontiers in Cell and Developmental Biology, 2021 Patients with the severe form of hemophilia A (HA) present with a severe phenotype, and can suffer from life-threatening, spontaneous hemorrhaging. While prophylactic FVIII infusions have revolutionized the clinical management of HA, this treatment is ...Christopher Stem, Christopher Rodman, Ritu M. Ramamurthy, Sunil George, Diane Meares, Andrew Farland, Anthony Atala, Christopher B. Doering, H. Trent Spencer, Christopher D. Porada, Graça Almeida-Porada +10 moredoaj +1 more sourceImplementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory [PDF]
, 2016 Objectives: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15-month experience on clinical samples.De Smet, Matthias, Dheedene, Annelies, Grisart, Bernard, Janssens, Sandra, Menten, Björn, Sante, Tom, Vanbellinghen, Jean-François, Vergult, Sarah +7 morecore +2 more sourcesMaternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nature Genetics, 2018 Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes.N. Warrington, R. Beaumont, M. Horikoshi, F. Day, Ø. Helgeland, Ø. Helgeland, Ø. Helgeland, Charles Laurin, Charles Laurin, J. Bacelis, Shouneng Peng, K. Hao, B. Feenstra, A. Wood, A. Mahajan, J. Tyrrell, J. Tyrrell, N. Robertson, N. W. Rayner, Zhen Qiao, G. Moen, G. Moen, M. Vaudel, C. Marsit, Jia Chen, M. Nodzenski, T. Schnurr, M. Zafarmand, J. Bradfield, N. Grarup, Marjolein N. Kooijman, Ruifang Li-Gao, F. Geller, T. Ahluwalia, L. Paternoster, R. Rueedi, R. Rueedi, V. Huikari, J. Hottenga, L. Lyytikäinen, A. Cavadino, A. Cavadino, S. Metrustry, D. Cousminer, D. Cousminer, Ying Wu, E. Thiering, Carol A. Wang, C. Have, N. Vilor‐Tejedor, Peter K. Joshi, J. Painter, I. Ntalla, Ronny Myhre, N. Pitkänen, E. M. Leeuwen, R. Joro, V. Lagou, V. Lagou, R. Richmond, R. Richmond, Ana Espinosa, S. Barton, H. Inskip, H. Inskip, J. Holloway, L. Santa-Marina, X. Estivill, W. Ang, J. Marsh, C. Reichetzeder, L. Marullo, B. Hocher, K. Lunetta, J. Murabito, C. Relton, C. Relton, M. Kogevinas, L. Chatzi, Catherine Allard, L. Bouchard, L. Bouchard, M. Hivert, M. Hivert, Ge Zhang, Ge Zhang, L. Muglia, L. Muglia, Jani Heikkinen, C. S. Morgen, A. Kampen, A. Kampen, Barbera D. C. Schaik, F. Mentch, C. Langenberg, J. Luan, R. Scott, Jing Hua Zhao, G. Hemani, G. Hemani, S. Ring, S. Ring, A. Bennett, K. Gaulton, K. Gaulton, J. Fernández-Tajes, N. Zuydam, C. Medina-Gomez, H. G. D. Haan, F. Rosendaal, Z. Kutalik, Z. Kutalik, P. Marques-Vidal, Shikta Das, G. Willemsen, H. Mbarek, M. Müller-Nurasyid, M. Standl, E. V. Appel, C. Fonvig, C. Trier, Catharina E. M. van Beijsterveldt, M. Murcia, M. Murcia, M. Bustamante, M. Bustamante, S. Bonàs-Guarch, D. Hougaard, J. Mercader, J. Mercader, J. Mercader, A. Linneberg, Katharina E. Schraut, P. Lind, S. Medland, B. Shields, B. Knight, Jin-Fang Chai, K. Panoutsopoulou, M. Bartels, Friman Sánchez, J. Stokholm, D. Torrents, R. Vinding, Sara M. Willems, M. Atalay, B. Chawes, P. Kovacs, I. Prokopenko, I. Prokopenko, M. Tuke, H. Yaghootkar, K. Ruth, Samuel E. Jones, Po-Ru Loh, Po-Ru Loh, A. Murray, M. Weedon, A. Tönjes, M. Stumvoll, K. Michaelsen, Aino-Maija Eloranta, T. Lakka, C. Duijn, W. Kiess, A. Körner, H. Niinikoski, H. Niinikoski, K. Pahkala, O. Raitakari, O. Raitakari, B. Jacobsson, B. Jacobsson, E. Zeggini, G. Dedoussis, Y. Teo, S. Saw, G. Montgomery, H. Campbell, James F. Wilson, T. Vrijkotte, M. Vrijheid, M. Vrijheid, E. D. Geus, M. Hayes, H. Kadarmideen, J. Holm, L. Beilin, C. Pennell, Joachim Heinrich, L. Adair, J. Borja, K. Mohlke, J. Eriksson, J. Eriksson, E. Widén, A. Hattersley, A. Hattersley, T. Spector, M. Kähönen, J. Viikari, J. Viikari, T. Lehtimäki, D. Boomsma, S. Sebert, P. Vollenweider, T. I. Sørensen, T. I. Sørensen, H. Bisgaard, K. Bønnelykke, J. Murray, M. Melbye, E. Nøhr, D. Mook-Kanamori, F. Rivadeneira, A. Hofman, J. Felix, V. Jaddoe, T. Hansen, C. Pisinger, A. Vaag, O. Pedersen, A. Uitterlinden, M. Järvelin, C. Power, Elina Hyppönen, Elina Hyppönen, D. Scholtens, W. Lowe, G. D. Smith, G. D. Smith, N. Timpson, N. Timpson, Andrew P Morris, Andrew P Morris, Andrew P Morris, N. Wareham, H. Hakonarson, H. Hakonarson, S. Grant, T. Frayling, D. Lawlor, D. Lawlor, P. Njølstad, P. Njølstad, S. Johansson, S. Johansson, K. Ong, M. McCarthy, M. McCarthy, J. Perry, David M. Evans, David M. Evans, David M. Evans, R. Freathy, R. Freathy +255 moresemanticscholar +1 more sourceTherapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim +18 morewiley +1 more sourceTransplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.
Blood, 2011 Osteogenesis imperfecta (OI or brittle bone disease) is a disorder of connective tissues caused by mutations in the collagen genes. We previously showed that intrauterine transplantation of human blood fetal stem/stromal cells in OI mice (oim) resulted ...M. Vanleene, Zahraa Saldanha, Kristy L. Cloyd, G. Jell, George Bou-Gharios, J. Bassett, G. Williams, N. Fisk, M. Oyen, M. Stevens, P. Guillot, S. Shefelbine +11 moresemanticscholar +1 more sourceEvaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled +10 morewiley +1 more sourcePlacental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy
Advanced Science, 2022 Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison +13 moredoaj +1 more source
