Results 41 to 50 of about 15,951,746 (312)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Progress Report (2014-2015) of the MDB Working Group on Sustainable Transport [PDF]

, 2015
1. In the third year of the Multilateral Development Banks¿1 (MDBs) Joint Statement of 2012, our eight MDBs are on target to meet the goal of the Commitment to Sustainable Transport (hereafter the Rio+20 Commitment) to provide more than $175 billion of ...
Inter-American Development Bank
core   +1 more source

Loss of NSD2 causes dysregulation of synaptic genes and altered H3K36 dimethylation in mice

Frontiers in Genetics
Background: Epigenetic disruptions have been implicated in neurodevelopmental disorders. NSD2 is associated with developmental delay/intellectual disability; however, its role in brain development and function remains unclear.Methods: We performed ...
Shiori Kinoshita, Shiori Kinoshita, Kazuaki Kojima, Eriko Ohnishi, Yuka Takayama, Hiroki Kikuchi, Shuji Takada, Kazuhiko Nakabayashi, Tomoko Kawai, Kenichiro Hata, Kenichiro Hata   +10 more
doaj   +1 more source

Lists of HumanMethylation450 BeadChip probes with nucleotide-variant information obtained from the Phase 3 data of the 1000 Genomes Project

Genomics Data, 2016
The Illumina's Infinium HumanMethylation450 (HM450) BeadChip array provides a simultaneous examination of DNA methylation status of more than 480,000 CpG sites in the human genome.
Kohji Okamura, Tomoko Kawai, Kenichiro Hata, Kazuhiko Nakabayashi   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Prenatal diagnosis of congenital thyroid teratoma

Journal of Pediatric Surgery Case Reports, 2020
We report a case of congenital thyroid teratoma that was diagnosed in fetal life and completely excised after birth. The histopathological diagnosis was immature teratoma.
Teizaburo Mori, Yumi Kudo, Yutaka Kanamori, Kazunori Tahara, Yohei Yamada, Mai Kutsukake, Takuro Fujita, Kazue Miyake, Akihiro Fujino, Nozomi Takahashi, Noriko Morimoto, Yohei Kosugi, Yoji Uehara, Yushi Ito, Osamu Miyazaki, Rika Sugibayashi, Katsusuke Ozawa, Seiji Wada, Haruhiko Sago   +18 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A sensitive method for analyzing fluconazole in extremely small volumes of neonatal serum

Journal of Pharmaceutical Health Care and Sciences, 2020
Background The need for a large volume of serum sample significantly reduces the feasibility of neonatal pharmacokinetic studies in daily practice, which must often rely on scavenged or opportunistic sampling.
Jumpei Saito, Ayano Tanzawa, Yuka Kojo, Hidehiko Maruyama, Tetsuya Isayama, Kensuke Shoji, Yushi Ito, Akimasa Yamatani   +7 more
doaj   +1 more source

Effects of melanocortins on fetal development [PDF]

Congenital Anomalies, 2011
ABSTRACTMelanocortins, adrenocorticotropic hormone (ACTH) and α‐, β‐, and γ‐melanocyte‐stimulating hormone (MSH) are produced in the placenta and secreted into embryos/fetuses. ACTH concentrations are higher in fetal plasma than in maternal plasma and peak at mid‐gestation in rats, whereas ACTH production starts in the anterior lobe of the fetal ...
Eriko, Simamura, Hiroki, Shimada, Hiroki, Shoji, Hiroki, Otani, Toshihisa, Hatta   +4 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source