Results 81 to 90 of about 938,719 (314)

Fetal testosterone and autistic traits [PDF]

, 2009
Studies of amniotic testosterone in humans suggest that fetal testosterone (fT) is related to specific (but not all) sexually dimorphic aspects of cognition and behaviour.
Kevin Taylor, Simon Baron‐Cohen, Bonnie Auyeung, Rebecca Knickmeyer, Knickmeyer, Rebecca, Ashwin, Emma, Auyeung, Bonnie; id_orcid, Gerald Hackett, Taylor, Kevin, Hackett, Gerald, Emma Ashwin, Baron-Cohen, Simon   +11 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Prolonged administration of ritodrine hydrochloride in women with premature labor or threatened premature delivery based on empirical data in Japan

Scientific Reports
In Japan, maintenance tocolysis has been conventionally administered. The current study aimed to identify the annual trends in the prolonged administration of ritodrine hydrochloride and its differences in terms of region and type of facility. This study
Kohei Ogawa, Daisuke Shinjo, Tomo Suzuki, Hiromitsu Azuma, Seiji Wada, Kiyohide Fushimi   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy.

, 2014
OBJECTIVES: There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations.
Villar, J, L J Salomon, J Villar, Victora, C. G., Victora, CG, Noble, J. A., Papageorghiou, A. T., Ismail, L. Cheikh, Cheikh Ismail, L, Noble, JA, Kennedy, S. H., E O Ohuma, Ohuma, Eric, R Pang † †, Jaffer, YA, A T Papageorghiou, Dr A Papageorghiou, Altman, DG, Gravett, M. G., Z A Bhutta, Pang, R., Lambert, Ann, J A Noble, Bhutta, ZA, S H Kennedy, Salomon, L. J., Pang, R, Villar, J., M Carvalho, L Cheikh Ismail, Bertino, E., Carvalho, M., Gravett, MG, Altman, D. G., Purwar, M., Bertino, E, C G Victora ¶, #z A B, Kennedy, Stephen, Y A Jaffer, Carvalho, M, E Bertino, International Fetal and Newborn Growth Consortium for the 21st C, Villar, Jose, § § §#, Barros, FC, J, A Lambert, M Purwar ¶ ¶, Kennedy, SH, Papageorghiou, Aris, D G Altman, Lambert, A., Altman, Doug, Ohuma, E. O., M G Gravett § §, Jaffer, Y. A., Salomon, LJ, Lambert, A, F C Barros § ¶, Purwar, M, Carvalho, Maria, Ohuma, EO, Bhutta, Z. A., Papageorghiou, AT, Barros, F. C.   +65 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prediction of fetal Graves’ disease among pregnant women with Graves’ disease who have undergone thyroidectomy or radioactive iodine therapy: A retrospective observational study

Endocrine Journal
Pregnant women with Graves’ disease (GD) who have undergone thyroidectomy or radioactive iodine therapy can have high levels of thyroid-stimulating hormone (TSH) receptor antibodies, which are transferred to the fetus via the placenta, posing a risk for ...
Aiko Hosoda, Naoko Arata, Nagayoshi Umehara, Shiori Sato, Akiko Sankoda, Yuko Iimura, Asako Mito, Chie Nagata, Seiji Wada, Haruna Kawaguchi, Masako Waguri, Nobuaki Mitsuda, Hitoshi Shimano   +12 more
doaj   +1 more source

Fetal alcohol spectrum disorders: strategies to address information gaps [PDF]

, 2014
Fetal Alcohol Spectrum Disorders (FASD) is emerging as a public health issue in Australia. Health-care providers and policy makers need accurate and timely data in a useable format to monitor and prevent FASD.

core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source