Results 101 to 110 of about 938,719 (314)

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

BMC Cancer, 2018
Background C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC).
Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus concepti and not correlated with fetal weight [PDF]

, 2013
The insulin-like growth factor 2 receptor (IGF2R) is essential for prenatal growth regulation and shows gene dosage effects on fetal weight that can be affected by in-vitro embryo culture.
Eckhard Wolf, Horst-Dieter Reichenbach, Ivica Medugorac, Reichenbach Myriam, Stefan Hiendleder (103381), Susanne E. Ulbrich (116395), Hiendleder Stefan, Ulbrich, S., Stefan Hiendleder, Fürst, Rainer W, Bebbere, D., Daniela Bebbere (400357), Horst-Dieter Reichenbach (212841), Wolf Eckhard, Rainer W. Fürst (385591), Ulbrich, Susanne E., Reichenbach, M., Reichenbach, H., Reichenbach Horst-Dieter, Bauersachs, Stefan, Wolf, E., Fürst, Rainer W., Ulbrich, Susanne E, Rainer W Fürst, Eckhard Wolf (39870), Reichenbach, Myriam, Bebbere Daniela, Furst, R., Stefan Bauersachs (130224), Hiendleder, S., Bauersachs Stefan, Susanne E Ulbrich, Sergio Ledda (400358), Reichenbach, Horst-Dieter, Myriam Reichenbach, Myriam Reichenbach (212830), Medugorac, I., Medugorac Ivica, Stefan Bauersachs, Hiendleder, Stefan, Bebbere, Daniela, Bauersachs, S., Ledda Sergio, Sergio Ledda, Ledda, S., Ivica Medugorac (157507), Wolf, Eckhard, Fürst Rainer W., Medugorac, Ivica, Ledda, Sergio, Daniela Bebbere, Ulbrich Susanne E.   +51 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The effects of unintended pregnancy on maternal bonding impairment among Japanese mothers: a longitudinal study from pregnancy to one month postpartum

BMC Pregnancy and Childbirth
Background Numerous studies have been conducted regarding maternal bonding; however, there is a lack of studies investigating the association with unintended pregnancy.
Hitoshi Kaneko, Yuya Makino, Mami Nakano, Yuichiro Takahashi, Masako Matsui, Kazuyo Ogawa   +5 more
doaj   +1 more source

Mathematical reappraisal of the congenital cystic adenomatoid malformation volume ratio

The Journal of Maternal-Fetal & Neonatal Medicine
Objective The CCAM (CPAM) volume ratio (CVR), an ultrasound index to predict hydrops or neonatal demise in fetuses affected with CPAM, is presumed to be independent of gestational age. A CVR of 1.6 has been proposed as predictive of hydrops.
Eftichia Kontopoulos, Luis F. Quintero, Alexandros Quintero Kontopoulos, Ramen H. Chmait, Thora Steffensen, Ruben Quintero   +5 more
doaj   +1 more source

Fetal alcohol spectrum disorders: current issues in awareness, prevention and intervention [PDF]

, 2014
This paper reviews the research and current policy surrounding prenatal alcohol exposure and fetal alcohol spectrum disorders (FASD). Alcohol use during pregnancy is linked to a spectrum of adverse fetal outcomes.
Sara McLean, Stewart McDougall
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source