Results 101 to 110 of about 559,832 (299)

Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate

Biomedicine Hub
Introduction: Monogenic diseases can be diagnosed before birth. Systemic fetal administration of nanoparticles (NPs) grants therapeutic access to developing stem cell populations impacted by these classes of disease.
David A. Eaton, Anna Y. Lynn, Juliana M. Surprenant, Emily I. Deschenes, Mary Elizabeth Guerra, Rachel Rivero, Nicholas K. Yung, Merissa O'Connor, Peter M. Glazer, Mert Ozan Bahtiyar, W. Mark Saltzman, David H. Stitelman   +11 more
doaj   +1 more source

Advancement in research on genes associated with fetal congenital heart disease (CHD) and diagnostic testing methods

, 2023
Junshu Xie, Kexin Zhang, Xiaohong Zhang
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Fetal imaging prompts maternal diagnosis: autosomal dominant polycystic kidney disease [PDF]

, 2015
Anna G. Euser, Joyce F. Sung, Shane Reeves   +2 more
openalex   +1 more source

Assessment of the anti-nociceptive effects of fetal ventral mesencephalic tissue allografts in a rat model of hemi-Parkinson’s disease using fMRI [PDF]

, 2022
Chuang‐Hsin Chiu, Shao‐Ju Weng, Skye Hsin‐Hsien Yeh, Yun-Ting Jhao, Hsien-Feng Chang, Wen-Sheng Huang, Cheng-Yi Cheng, Chun‐Chang Yeh, Kuo‐Hsing Ma   +8 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Reduced fetal cerebral oxygen consumption is associated with abnormal white matter in newborns with congenital heart disease [PDF]

, 2015
Prakash Muthusami, Sujana Madathil, Susan Blasér, Edgar Jaeggi, Lars Grosse‐Wortmann, Shi‐Joon Yoo, John‏ Kingdom, Edward Hickey, John G. Sled, Christopher K. Macgowan, Steven P. Miller, Mike Seed   +11 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Maternal and Fetal Origins of Cardiovascular Disease [PDF]

, 1994
CN Martyn, D.J.P. Barker
openalex   +1 more source