Results 141 to 150 of about 9,877,071 (357)

Fetal ascites: an unusual presentation of Niemann-Pick disease type C. [PDF]

open access: bronze, 1989
Ian Maconochie   +4 more
openalex   +1 more source

Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate

open access: yesBiomedicine Hub
Introduction: Monogenic diseases can be diagnosed before birth. Systemic fetal administration of nanoparticles (NPs) grants therapeutic access to developing stem cell populations impacted by these classes of disease.
David A. Eaton   +11 more
doaj   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2 [PDF]

open access: bronze, 1992
GJ Dover   +7 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Autologous Adrenal Medullary, Fetal Mesencephalic, and Fetal Adrenal Brain Transplantation in Parkinson′s Disease: A Long‐Term Postoperative Follow‐Up [PDF]

open access: gold, 1991
Ignacio Madrazo   +8 more
openalex   +1 more source

L-FUSION: Laplacian Fetal Ultrasound Segmentation & Uncertainty Estimation [PDF]

open access: yesarXiv
Accurate analysis of prenatal ultrasound (US) is essential for early detection of developmental anomalies. However, operator dependency and technical limitations (e.g. intrinsic artefacts and effects, setting errors) can complicate image interpretation and the assessment of diagnostic uncertainty.
arxiv  

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