Results 151 to 160 of about 9,877,071 (357)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Fetal ascites: an unusual presentation of Niemann-Pick disease type C. [PDF]

, 1990
David Manning, W I Price, Robin Pearse
openalex   +1 more source

Single-cell reconstruction of the early maternal–fetal interface in humans

Nature, 2018
R. Vento-Tormo, M. Efremova, R. Botting, M. Turco, Miquel Vento-Tormo, K. Meyer, Jong-Eun Park, Emily Stephenson, K. Polański, Ângela Gonçalves, L. Gardner, S. Holmqvist, J. Henriksson, Angela E. Zou, A. Sharkey, Ben Millar, B. Innes, Laura Wood, A. Wilbrey-Clark, R. Payne, M. Ivarsson, S. Lisgo, A. Filby, D. Rowitch, J. Bulmer, Gavin J. Wright, Michael J. T. Stubbington, M. Haniffa, A. Moffett, S. Teichmann   +29 more
semanticscholar   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Fetal and infantile hypertension caused by unilateral renal arterial disease. [PDF]

, 1990
David I. Wilson, Richard Appleton, Malcolm Coulthard, R E Lee, Christopher Wren, H H Bain   +5 more
openalex   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Fetal leucocyte count in rhesus disease. [PDF]

, 1992
Norman Davies, Andrea G.S. Buggins, R. J. M. Snijders, P-Morgan-Capner Noble, D. Mark Layton, K. H. Nicolaides   +5 more
openalex   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Fetal origins of adult disease

Korean Journal of Obstetrics and Gynecology, 2010
성인기의 건강과 질병이 생애 초기 발달과정과 출생 후 초기 발달과정에 의해 결정되고 영향을 받을 수 있다는 이론은 역학연구와 동물 실험연구를 통해 입증되었다. 이들 이론들을 바탕으로 태아기의 부적절한 환경에 대한 적응이 각 개체의 생존을 위한 방식으로 작용되는 형질 발현의 결과로 다양한 만성 성인병들이 발생한다는 발달프로그래밍 가설 (developmental programming hypothesis)이 제기되었다. 각 개체의 발달은 유전학적 인자뿐만 아니라 생애기 초기의 환경적 요인과 생활 습관 등에 의해 영향을 받을 수 있다.
openaire   +2 more sources