Results 161 to 170 of about 886,120 (360)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Artificial intelligence, fetal echocardiography, and congenital heart disease [PDF]

, 2021
Thomas G. Day, Bernhard Kainz, Joseph V. Hajnal, Reza Razavi, John Simpson   +4 more
openalex   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

The Long and Short of It: The Role of Telomeres in Fetal Origins of Adult Disease [PDF]

, 2012
Stephanie E Hallows, Timothy R.H. Regnault, Dean H. Betts   +2 more
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Fetal development of regulatory mechanisms for body fluid homeostasis

Brazilian Journal of Medical and Biological Research, 2008
The balance of body fluids is critical to health and the development of diseases. Although quite a few review papers have shown that several mechanisms, including hormonal and behavioral regulation, play an important role in body fluid homeostasis in ...
J. Guan, C. Mao, X. Feng, H. Zhang, F. Xu, C. Geng, L. Zhu, A. Wang, Z. Xu   +8 more
doaj  

Fetal origins of adult disease [PDF]

British Journal of Nutrition, 1999
openaire   +2 more sources

SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease [PDF]

Rachel M. Levine, Erin Dempsey, Nikitha Nimmagadda, Yoonjeong Jang, Kalin Mayberry, Jingjing Zhang, David Cullins, Catherine Willis, Alicia Powers, Young-In Kim-Hoehammer, Jie Lin, Fei Zhang, Neha Gupta, Will Lewis, Varun Katta, Yichao Li, Timothy Lockey, Yong Cheng, Patti Lehigh, Frank Fazio, Alexis Leonard, Akshay Sharma, Sheng Zhou, Shengdar Q. Tsai, Mitchell J. Weiss, Jonathan Yen   +25 more
openalex   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Modeling Congenital Heart Disease in Mice and Assessing its Effects on Fetal Brain Development

, 2023
Anum Rahman
openalex   +1 more source