Results 151 to 160 of about 1,194,310 (307)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Hemodynamic changes in pregnancies with impaired fetal growth: A systematic review and meta-analysis. [PDF]

Acta Obstet Gynecol Scand
Kempener BMJG, Jorissen LM, Mulder EG, Ghossein-Doha C, van Drongelen J, Scholten RR, Lees CC, de Haas S, Janssen EBNJ, Spaanderman MEA.   +9 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The role of vitamin D deficiency in fetal growth restriction: a systematic review. [PDF]

Front Med (Lausanne)
Octavia L, Nabila P, Panjarwanto DA, Geany PL, Kosen YD, Rahman AA, Yora VS, Javier RM, Haekal M, Sutanto L, Tandayu AP, Varsha S, Putra MDE, Cita AA, Maharani BS, Nuruddin MFG, Salsabila S, Friska DFH.   +17 more
europepmc   +1 more source

Dimensions and Determinants of Early Childhood Health and Mortality Among American Slaves [PDF]

This paper relies on birth and death lists from plantation records to investigate the causes of low birth weight and poor health of young slave children. The sources of deprivation can be traced to the fetal period.
Richard H. Steckel
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Antenatal melatonin for cardiovascular deficits in fetal growth restriction. [PDF]

J Physiol
Rock CR, White TA, Piscopo BR, Sutherland AE, Pham Y, Karozis C, Cousins FL, Camm EJ, Miller SL, Allison BJ.   +9 more
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Multivariate fetal growth trajectory modeling and its association with maternal fatty acids. [PDF]

Sci Rep
Huang S, Tang JJ, Chi HB, Zhang HW, Fan XY, Tang F, Lin XS, Yang BR, Qi HB, Xia YY, Han TL, Zhang H.   +11 more
europepmc   +1 more source