Results 71 to 80 of about 5,983,305 (250)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Minia Journal of Medical Research:A major factor altering fetal renal development intrauterine is fetal growth restriction (FGR).Diminished blood circulatory flow to the kidneys because of fetal hypoxia in FGR fetus causes elevated pulsatile index which could be liable for inadequate ...
Ahmed Rashed +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Environmental Health, 2019 Background Non-persistent chemicals, such as phthalates, environmental phenols, organophosphate pesticides, and others, are challenging to study because of their ubiquity in the environment, diverse exposure routes, and high temporal variability of ...
Elizabeth M. Kamai +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The effects of asymmetric and symmetric fetal growth restriction on human capital development [PDF]
This paper explores the causal pathway by which poor fetal health translates into reducing educational attainment and earnings as an adult. Using insights from the medical literature, I decompose low birth weight infants into two distinct subtypes: a ...
Robinson, Joshua J
core
, 2007 Objective. To verify the correlation of fetal cerebellar volume by three- dimensional ultrasound ( 3D US) with other indices of fetal growth in normal fetuses.Methods.
Moron, Antonio Fernandes [UNIFESP] +4 more
core +1 more source
Women's experience of coping with termination of pregnancy for fetal abnormality: coping strategies, perinatal grief and posttraumatic growth [PDF]
Pregnancy termination for fetal abnormality (TFA) represents 2% of all terminations in England and Wales. In recent years, the number of TFAs has risen (3,099 in 2014 compared to 2,085 in 2009) due to technological developments in prenatal diagnosis and ...
Lafarge, Caroline
core +3 more sources
Radiological Modalities for the Assessment of Fetal Growth Restriction: A Comprehensive Review
مجله كليه طب الكنديFetal growth restriction is a significant contributor to fetal morbidity and mortality. In addition, there are heightened maternal risks associated with surgical operations and their accompanying dangers.
shaymaa Abdulqader +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source