Results 101 to 110 of about 260,729 (263)

Classification of stillbirths is an ongoing dilemma [PDF]

, 2016
Aim: To compare different classification systems in a cohort of stillbirths undergoing a comprehensive workup; to establish whether a particular classification system is most suitable and useful in determining cause of death, purporting the lowest ...
Bonaccorsi, Gloria, Borghi, Chiara, Bufo, Pantaleo, Fineschi, Vittorio, Greco, Pantaleo, Nappi, Luigi, Riezzo, Irene, Scutiero, Gennaro, Trezza, Federica, Turillazzi, Emanuela   +9 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Longitudinal study of computerised cardiotocography in early fetal growth restriction. [PDF]

, 2016
OBJECTIVES: To explore if in early fetal growth restriction (FGR) the longitudinal pattern of short-term fetal heart rate (FHR) variation (STV) can be used for identifying imminent fetal distress and if abnormalities of FHR registration associate with ...
Aktas, A. (Ayse), Arabin, B. (Birgit), Bilardo, C.M. (Caterina Maddalena), Borgione, S. (Silvia), Brezinka, C.A. (Christoph), Calvert, S. (Sandra), Chaoui, R. (R.), Cornette, J.M.J. (Jerome M. J.), Derks, J.B. (Jan), Diehl, T. (Thilo), Diemert, A. (Anke), Duvekot, J.J. (Hans), Eyck, J. (Jim) van, Ferrazzi, E. (Enrico), Fratelli, N. (N.), Frusca, T. (T.), Ganzevoort, W. (Wessel), Hecher, K. (Kurt), Johnson, S. (Samantha), Lees, C. (Christoph), Lobmaier, S. (Silvia), Lopriore, E., Mansi, G. (Giuseppina), Marlow, N. (Neil), Martelli, P. (Paola), Martinelli, P. (Pasquale), Maso, G. (G.), Maurer-Fellbaum, U. (Ute), Missfelder-Lobos, H. (H.), Moore, T. (Tamanna), Napolitano, R. (Raffaele), Oberto, M. (M.), Oepkes, D., Ogge, G. (G.), Ostermayer, E. (Eva), Papageorghiou, A.T. (A.), Post, J.A.M. (Joris) van der, Prefumo, F. (F.), Preston, L. (Lucy), Raimondi, F. (Francesco), Reiss, I.K.M. (Irwin), Rigano, S. (Serena), Scheepers, H.C.J. (Hubertina), Schlembach, D. (Dietmar), Schneider, K.T.M. (K. T.M.), Schuit, E. (Ewoud), Skabar, A. (Aldo), Spaanderman, M.E.A., Thilaganathan, B. (Baskaran), Todros, T. (Tullia), Tollenaer, S.M. (S.) de, Valcamonico, A. (Adriana), Van Charante, N.M. (Nico Mensing), van Haastert, I.-L. (Inge-Lot), Visser, G.H. (Gerhard Henk), Wassenaer-Leemhuis, A.G. (Aleid) van, Weisglas–Kuperus, N. (Nynke), Wolf, H. (Hans Uwe), Zimmermann, A. (Andrea)   +58 more
core   +6 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Fetal ultrasound measurements and associations with postnatal outcomes in infancy and childhood : a systematic review of an emerging literature [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer ...
Alkandari, Farah, Aucott, Lorna, Devereux, Graham, Ellahi, Awaiss, Turner, Steve   +4 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Investigating the Potential of Sildenafil in Mitigating Fetal Growth Restriction: A Study on Experimentally Restricted Fetal Growth Rats [PDF]

Iranian Journal of Veterinary Surgery
Intrauterine growth restriction (IUGR) is a common pregnancy complication. Sildenafil is also emerging as a potential candidate for the treatment of IUGR.
Ghasem Akbari, Siamak Kazemi-Darabadi, Mehdi Basaki, Meysam Karami, Pardis Elmdoustazar   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Effects of maternal subnutrition during early pregnancy on cow hematological profiles and offspring physiology and vitality in two beef breeds [PDF]

, 2019
This experiment evaluated the effects of subnutrition during early gestation on hematology in cows (Bos Taurus) and on hematological, metabolic, endocrine, and vitality parameters in their calves.
Almaguer C., Civelek T., Fay R. A., García‐Belenguer S., Krimer P. M., Lozano M., Schafer S., Schultz R. D., Tchernia G., Tennant B.   +9 more
core   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source