Results 81 to 90 of about 5,634,776 (298)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Proteomic analyses in early brain development and neuropathological implications of fetal growth restriction

Neural Regeneration Research
Proteins are the primary functional units within cells, driving complex biological processes essential for stem cell differentiation into specific neural lineages and for the structural and functional maturation of the central nervous system. Advances in
Gemma C. Ventura, Kirat K. Chand, Paul B. Colditz, Julie A. Wixey   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effects of asymmetric and symmetric fetal growth restriction on human capital development [PDF]

This paper explores the causal pathway by which poor fetal health translates into reducing educational attainment and earnings as an adult. Using insights from the medical literature, I decompose low birth weight infants into two distinct subtypes: a ...
Robinson, Joshua J
core  

Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age [PDF]

, 2002
Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure ...
Shinebourne, EA, Syddall, H.E., Law, CM, Fayers, PM, A.W. Shiell, E.A. Shinebourne, Shinebourne, E.A., Shiell, AW, C.M. Law, Newsome, C.A., Martyn, C.N., M. de Swiet, Newsome, CA, Martyn, CN, de Swiet, M, H.E. Syddall, P.M. Fayers, C.N. Martyn, Syddall, HE, De Swiet, M., Fayers, P.M., C.A. Newsome, Law, C.M., Shiell, A.W.   +23 more
core   +1 more source

Infant factors associated with fetal growth restriction.

, 2022
Infant factors associated with fetal growth restriction.
Shunichiro Tsuji (4816458), Shumpei Obata (11237777), Takahide Yanagi (5859359), Takashi Murakami (138867), Masahito Ohji (2560828), Riko Matsumoto (11824673), Masashi Kakinoki (6519578), Yoshihiro Maruo (8982578)   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation

Molecular Metabolism, 2020
Objective: The importance of the placenta in mediating the pre- and post-natal consequences of fetal growth restriction has been increasingly recognized.
Colette N. Miller, Janice A. Dye, Andres R. Henriquez, Erica J. Stewart, Katelyn S. Lavrich, Gleta K. Carswell, Hongzu Ren, Danielle L. Freeborn, Samantha J. Snow, Mette C. Schladweiler, Judy H. Richards, Prasada R.S. Kodavanti, Anna Fisher, Brian N. Chorley, Urmila P. Kodavanti   +14 more
doaj   +1 more source

Maternal factors associated with fetal growth restriction.

, 2022
Maternal factors associated with fetal growth restriction.
Shunichiro Tsuji (4816458), Shumpei Obata (11237777), Takahide Yanagi (5859359), Takashi Murakami (138867), Masahito Ohji (2560828), Riko Matsumoto (11824673), Masashi Kakinoki (6519578), Yoshihiro Maruo (8982578)   +7 more
core   +1 more source