Results 81 to 90 of about 260,729 (263)

Fetal Growth Restriction - a 4-Year Case Series [PDF]

, 2013
Overview and aims: Fetal growth restriction (FGR) affects 15% of pregnancies and is associated with both increased perinatal and neonatal morbidity and mortality and long-term effects in adult life. Our aim was to describe cases and outcomes of FGR from
Figueiredo, A, Martins, AT, Martins, I, Pedroso, C, Ribeiro, F, Robalo, R   +5 more
core  

Treatment of poor placentation and the prevention of associated adverse outcomes--what does the future hold? [PDF]

, 2014
Poor placentation, which manifests as pre-eclampsia and fetal growth restriction, is a major pregnancy complication. The underlying cause is a deficiency in normal trophoblast invasion of the spiral arteries, associated with placental inflammation ...
Alers, Altman, American College of Obstetricians and Gynecologists Committee on Obstetric Practice Society for Maternal-Fetal Medicine, American College of Obstetricians and Gynecologists Committee on Obstetric Practice Society for Maternal-Fetal Medicine, Australian Research Centre for Health of Women and Babies, Bauer, Bisseling, Carney, Carr, Carr, Carr, Carter, Chang, Cindrova-Davies, Costantine, Costantine, Dadelszen, David, Doyle, Everett, Everett, Foidart, George, George, Gulmezoglu, Gulmezoglu, Hashimoto, Hobson, Holwerda, Johal, Kane, Konje, Lees, Lemley, Lyall, Lyerly, Makino, Manzur-Verastegui, Martin, Martinez-Abundis, McCowan, McCullough, Mehta, Mehta, Miller, Nanovskaya, National Collaborating Centre for Women's and Children's Health, Nevo, Ofori, Petersen, Raisanen, Rana, Redmer, Reeves, Richter, Robertson, Roes, Royal College of Obstetricians and Gynaecologists, Royal College of Obstetricians and Gynaecologists, Royal College of Obstetrics and Gynaecology, Rumbold, Salles, Samangaya, Samangaya, Savvidou, Say, Say, Say, Stanley, Suzuki, Thadhani, Wallace, Wang, Wang, Wareing, Wareing, Wing   +76 more
core   +3 more sources

MFM Guidance for COVID-19 [PDF]

, 2020
The World Health Organization (WHO) has declared COVID-19 a global pandemic. Healthcare providers should prepare internal guidelines covering all aspect of the organization in order to have their unit ready as soon as possible.
Bellussi, Federica, Berghella, Vincenzo, Boelig, Rupsa C., Saccone, Gabriele   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease. [PDF]

, 2019
Intrauterine growth restriction (IUGR) enhances risk for adult onset cardiovascular disease (CVD). The mechanisms underlying IUGR are poorly understood, though inadequate blood flow and oxygen/nutrient provision are considered common endpoints.
Casero, David, Chu, Alison, Cosi, Amy, Devaskar, Sherin U, Thamotharan, Shanthie, Wadehra, Madhuri   +5 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The hemodynamic repercussions of the autonomic modulations in growth-restricted fetuses

Alexandria Journal of Medicine, 2017
Objectives: Idiopathic fetal growth restriction is considered to be associated with hemodynamic abnormalities. The study was aimed to the investigation of the relationship between fetal and maternal autonomic balance, arterial and venous hemodynamic ...
Igor Victorovich Lakhno
doaj   +1 more source

Ozone-induced fetal growth restriction in rats is associated with sexually dimorphic placental and fetal metabolic adaptation

Molecular Metabolism, 2020
Objective: The importance of the placenta in mediating the pre- and post-natal consequences of fetal growth restriction has been increasingly recognized.
Colette N. Miller, Janice A. Dye, Andres R. Henriquez, Erica J. Stewart, Katelyn S. Lavrich, Gleta K. Carswell, Hongzu Ren, Danielle L. Freeborn, Samantha J. Snow, Mette C. Schladweiler, Judy H. Richards, Prasada R.S. Kodavanti, Anna Fisher, Brian N. Chorley, Urmila P. Kodavanti   +14 more
doaj   +1 more source

Birth outcomes of cases with different congenital heart defects - a population-based study [PDF]

, 2015
Background: In general, previous epidemiological studies evaluated congenital heart defects (CHDs) together. The aim of the present study was to identify possible etiological factors of different CHD-entities, because the underlying causes are unclear in
Czeizel, Andrew E., Gerencsér, Balázs, Szabó, István, Vereczkey, Attila   +3 more
core   +2 more sources