Results 61 to 70 of about 5,634,776 (298)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Fetal Growth Restriction and Postnatal Development

Annals of the New York Academy of Sciences, 2006
Abstract:  The interaction between genetic constitution and in utero environment determines fetal growth and development and influences the susceptibility to certain disorders in adulthood. Data from both animal and human studies indicate that prenatal and early postnatal malnutrition can program the hypothalamus‐pituitary‐adrenal axis (HPA axis ...
Eleftheriades, Makarios, Creatsas, George, Nicolaides, Kypros   +2 more
openaire   +3 more sources

Growth patterns of monochorionic twin pregnancies complicated by type-3 selective fetal growth restriction. [PDF]

, 2022
OBJECTIVE Little is known regarding fetal growth patterns of monochorionic twins complicated by type 3 selective fetal growth restriction (sFGR). We aimed to assess fetal growth and Doppler patterns in type 3 sFGR across gestation and evaluate the ...
F. Slaghekke, Dekoninck, P., DeKoninck, P, Van Mieghem, T, Baud, D., Mieghem, T. van, Yinon, Y, L. Lewi, Xing, W, Yinon, Y., Lewi, L., Huszti, E., Van Mieghem, T., P. DeKoninck, Slaghekke, F, Baud, D, L. Sun, T. Van Mieghem, Sun, L, S. Shinar, Y. Yinon, Shinar, S, Sun, L., D. Baud, Raio, L., L. Raio, E. Huszti, Melamed, N, N. Melamed, Melamed, N., W. Xing, Raio, L, Shinar, S., Lewi, L, Huszti, E, Xing, W., Slaghekke, F.   +36 more
core   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prevalence, interactions, determinants and outcomes of low birth weight, small for gestational age and fetal growth restriction among term neonates

BMC Pediatrics
Introduction Small for gestational age and fetal growth restriction are two leading causes for low birth weight in term newborns. Due to the considerable overlap, the exact interactions between these groups have not been adequately studied.
Sangeetha Wickramaratne, Gihan Gunarathna, Eshani Ranasinghe, Hesitha Nimana, Dinuka Kalhara, Sanjeevan Kanagarasa, Shammi Isanka, Tiran Dias, Rasika Herath, Nalin Gamaathige, Sachith Mettananda   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Hematological and biochemical findings in fetal growth restriction and the relationship to hypoxia

, 2018
Many factors influence the process of intrauterine growth so that some fetuses do not follow their growth potential. Intrauterine growth restriction (IUGR) is a complex disease with different severity depending on placental compromise.
I. Cetin, C. Mandò
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source