Results 61 to 70 of about 260,729 (263)

Can the cerebroplacental ratio (CPR) predict intrapartum fetal compromise? : a prospective observational study [PDF]

, 2017
Objective: To investigate the potential clinical use of serial fetal CPR measurements during the last month of pregnancy for the prediction of adverse perinatal outcome in unselected low-risk pregnancies.
Dehaene, Isabelle, Page, Ann-Sophie, Page, Geert, Roelens, Kristien, Roets, Ellen   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Prevalence, interactions, determinants and outcomes of low birth weight, small for gestational age and fetal growth restriction among term neonates

BMC Pediatrics
Introduction Small for gestational age and fetal growth restriction are two leading causes for low birth weight in term newborns. Due to the considerable overlap, the exact interactions between these groups have not been adequately studied.
Sangeetha Wickramaratne, Gihan Gunarathna, Eshani Ranasinghe, Hesitha Nimana, Dinuka Kalhara, Sanjeevan Kanagarasa, Shammi Isanka, Tiran Dias, Rasika Herath, Nalin Gamaathige, Sachith Mettananda   +10 more
doaj   +1 more source

MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]

, 2016
PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet, Avni, Reut, Biton, Inbal, Cohen, Yonni, Garbow, Joel R, Golani, Ofra, Neeman, Michael   +6 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Association between reduced stillbirth rates in England and regional uptake of accreditation training in customised fetal growth assessment [PDF]

, 2013
Objective: To assess the effect that accreditation training in fetal growth surveillance and evidence-based protocols had on stillbirth rates in England and Wales. Design: Analysis of mortality data from Office of National Statistics.
Clifford, Sally, Francis, A. (André), Gardosi, Jason, Giddings, Sally, Wood, Lynne   +4 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial [PDF]

, 2014
Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The
Atallah, Álvaro Nagib, Dos Santos, G.m.s., Kulay Jr, L., Sass, Nelson, Souza, E.v., Torloni, Maria Regina   +5 more
core   +2 more sources

International gestational age-specific centiles for umbilical artery Doppler indices: a longitudinal prospective cohort study of the INTERGROWTH-21st Project. [PDF]

, 2020
BACKGROUND: Reference values for umbilical artery Doppler indices are used clinically to assess fetal well-being. However, many studies that have produced reference charts have important methodologic limitations, and these result in significant ...
Barros, FC, Berkley, JA, Carvalho, M, Drukker, L, Kennedy, SH, McGready, R, Munim, S, Norris, SA, Nosten, F, Papageorghiou, AT, Staines-Urias, E, Uauy, R, Villar, J   +12 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source