Results 71 to 80 of about 5,634,776 (298)

Role of Transverse Cerebellar Diameter in Diagnosis of Asymmetrical Fetal Growth Restriction

Journal of Rawalpindi Medical College, 2013
Background: To evaluate the accuracy of transcerebellar diameter and transcerebellar diameter /abdominal circumference ratio (TCD/AC) as independent predictor for asymmetrical fetal growth restriction Methods: In this observational study 30 high risk ...
Nasir Khan
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction

Scientific Reports, 2022
Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction.
Ryo Kiyokoba, Takeshi Uchiumi, Mikako Yagi, Takahiro Toshima, Shigehiro Tsukahara, Yasuyuki Fujita, Kiyoko Kato, Dongchon Kang   +7 more
doaj   +1 more source

Maternal characteristics predisposing to fetal growth restriction

, 2017
Fetal growth restriction affects up to 10% of live-born infants representing a major cause of neonatal morbidity and mortality worldwide, being a significant risk factor for future adult health. A reduction of nutrient supply and oxygenation is the final
Francesca Parisi, Irene Cetin, Chiara Mandò   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sonographic Placental Aspects in Fetal Growth Restriction [PDF]

Fetal growth restriction (FGR) is a complication diagnosed in about 10% of pregnancies and is associated with significant perinatal mortality and morbidity.
Nastasia SERBAN, Elena-Adriana GHELMENE, Manuela Cristina RUSSU   +2 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Intrauterine Growth Restriction and Doppler Ultrasound [Intrauterin Gelisme Geriligi ve Doppler Ultrasonografi]

Medicine Science, 2016
Intrauterine growth restriction is an important perinatal problem giving rise to increased morbidity and mortality in the growth restricted fetus. Today the aim is to prevent the occurence of intrauterine growth restriction in high risk pregnancies and ...
Senem Arda Duz
doaj   +1 more source

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction [PDF]

, 2019
Background: Preeclampsia and fetal growth restriction share some pathophysiologic features and are both associated with placental insufficiency. Fetal cardiac remodeling has been described extensively in fetal growth restriction, whereas little is known ...
Sepulveda-Martinez, Alvaro, Gratacós, Eduard,, Crispi, Fatima,, Fatima Crispi, Miranda, Jezid, Olga Gomez, Gratacós, Eduard, Sepúlveda Martínez, Alvaro, Garcia-Otero, Laura,, Jezid Miranda, Garcia-Otero, Laura, Gomez, Olga, Kalapotharakos, Grigorios,, Vellvé, Kilian,, Crovetto, Francesca, Gomez, Olga,, Eduard Gratacós, Paules, Cristina, Crispi, Fatima, Youssef, Lina, Vellvé, Kilian, Grigorios Kalapotharakos, Miranda, Jezid,, García Otero, Laura, Alvaro Sepulveda-Martinez, Kilian Vellvé, Sepulveda-Martinez, Alvaro,, Youssef, Lina,, Francesca Crovetto, Lina Youssef, Kalapotharakos, Grigorios, Cristina Paules, Laura Garcia-Otero, Crovetto, Francesca,, Paules, Cristina,, Lund University.   +35 more
core   +1 more source

Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction: prospective cohort study [PDF]

, 2020
Objectives: To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction.
Graupner, O., Frusca, T.,, Cesari, E., Gordijn, S., Fantasia, I., Krofta, L.,, K. Hecher, Gordijn, S J, Bilardo, C. M., Brodszki, Jana, Raio, L.,, Calda, P., Maruotti, G. M.,, Gordijn, SJ, R. K. Sande, Maruotti, G M, Krofta, L, Prefumo, F.,, E. Cesari, Bhide, A, Ferrazzi, E.,, Breeze, A.C., Cesari, E, Cerny, A., Sande, R. K.,, H. Wolf, Marlow, N, Lobmaier, S M, Valensise, H., T. Stampalija, Papageorghiou, Aris, Calda, P.,, Pickles, T.,, Myklestad, K., TRUFFLE-2 Group, Presti, D. Lo, Wolf, H, Casagrandi, D., Gyselaers, W.,, Lees, C. C.,, Georg, Macharay Georg Macharey, Marlow, N.,, E. Ferrazzi, Lobmaier, S.M., Eggebo, T. M., Maruotti, G, G. H. A. Visser, Sande, R.K., Ferrazzi, E, Thornton, J.,, Macsali, F., Maruotti, G.M., Ebbing, C.,, P. Lindgren, Arabin, B.,, Stampalija, T.,, Ferrazzi, E., Eggebo, T., J. Richter, Maruotti, G., Bilardo, CM, Prefumo, F., Visser, GHA, Lees, C. C., Visser, G., Stampalija, T,, Stampalija, T., Brodszki, J.,, Visser, G. H. A.,, Ebbing, C., Lobmaier, S., Valensise, H, Mylrea-Foley, B., W. Gyselaers, J. Thornton, Greimel, P., Breeze, AC, Napolitano, R, Visser, G H A, Lobmaier, S. M.,, Cesari, E.,, Raio, L, Maruotti, GM, Tiralongo, G., Ganzevoort, W, Mecacci, F, Lobmaier, SM, Breeze, A, Bhide, A., Marsal, K., Ferrari, F., J. Brodszki, Vietheer, A., Lindgren, P, Ganzevoort, W.,, Derks, J, Breeze, A., N. Marlow, K. Myklestad, Richter, J., Van Holsbeke, C., Brodszki, J., Bergman, Eva, I. Fantasia, Martinelli, P., Wee, L, I. Cetin, Georg, M., A. Berger, F. Prefumo, Valensise, H.,, Arabin, B, Papageorghiou, A., TRUFFLE-2 Group, ., Frusca, T., B. Arabin, Berger, A., L. Krofta, Wee, L.,, Arabin, B., Lees, C.C., Brezinka, C., S. M. Lobmaier, Bhide, A.,, Marlow, N., Mylrea‐Foley, B., Berger, A, the TRUFFLE-2 Group, Lees, CC, Sande, R K, Gordijn, S. J., L. Wee, Visser, G, Sarno, L., Hofstaetter, C., Lees, C., T. Pickles, Lund University., A. Bhide, T. Frusca, Hecher, K.,, Thilaganathan, B., Sande, R. K., Lindgren, P., Klaritsch, P., Krofta, L., Hecher, K., Maruotti, G. M., Ostermayer, E., Mullins, E., R. Napolitano, Myklestad, K, Bergman, Eva,, Wolf, H.,, Bilardo, C. M.,, L. Raio, Peasley, R., Ghi, T., Richter, J, F. Mecacci, Lobmaier, S, Ebbing, C, P. Klaritsch, E. Bergman, Cetin, I.,, G. M. Maruotti, Pickles, T., Breeze, A. C.,, C. Ebbing, Bilardo, C.M., Brodszki, Jana,, Thornton, J., H. Valensise, Ramoni, A., Devlieger, R., Wolf, H., Lees, C, S. J. Gordijn, Gordijn, S. J.,, Lindgren, P.,, Derks, J.,, Simeone, S., Cetin, I, Mecacci, F., Brodszki, J, Ganzevoort, W., Raio, L., Cetin, I., Klaritsch, P.,, Wee, L., C. C. Lees, Thornton, J, Derks, J., Gyselaers, W, Berger, A.,, Lees, C C, A. C. Breeze, Napolitano, R.,, Myklestad, K.,, Klaritsch, P, Duvekot, J., Richter, J.,, Prefumo, F, Valcamonico, A., C. M. Bilardo, Bergman, E., Breeze, A. C., GYSELAERS, Wilfried, Hecher, K, Dall'Asta, A., Visser, G. H. A., Lobmaier, S. M., Seikku, L., Visser, G.HA., Sande, RK, Gordijn, S.J., Breeze, A C, P. Calda, Napolitano, R., Gyselaers, W., J. Derks, Pickles, T, Bilardo, C M, Frusca, T, Bergman, E, Calda, P, Stampalija, T, Fratelli, N., Gordijn, S, W. Ganzevoort, Mecacci, F.,   +230 more
core   +3 more sources