Results 71 to 80 of about 6,037,566 (297)

Hematological and biochemical findings in fetal growth restriction and the relationship to hypoxia

, 2018
Many factors influence the process of intrauterine growth so that some fetuses do not follow their growth potential. Intrauterine growth restriction (IUGR) is a complex disease with different severity depending on placental compromise.
I. Cetin, C. Mandò
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction

Scientific Reports, 2022
Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction.
Ryo Kiyokoba, Takeshi Uchiumi, Mikako Yagi, Takahiro Toshima, Shigehiro Tsukahara, Yasuyuki Fujita, Kiyoko Kato, Dongchon Kang   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction [PDF]

, 2019
Background: Preeclampsia and fetal growth restriction share some pathophysiologic features and are both associated with placental insufficiency. Fetal cardiac remodeling has been described extensively in fetal growth restriction, whereas little is known ...
Sepulveda-Martinez, Alvaro, Gratacós, Eduard,, Crispi, Fatima,, Fatima Crispi, Miranda, Jezid, Olga Gomez, Gratacós, Eduard, Sepúlveda Martínez, Alvaro, Garcia-Otero, Laura,, Jezid Miranda, Garcia-Otero, Laura, Gomez, Olga, Kalapotharakos, Grigorios,, Vellvé, Kilian,, Crovetto, Francesca, Gomez, Olga,, Eduard Gratacós, Paules, Cristina, Crispi, Fatima, Youssef, Lina, Vellvé, Kilian, Grigorios Kalapotharakos, Miranda, Jezid,, García Otero, Laura, Alvaro Sepulveda-Martinez, Kilian Vellvé, Sepulveda-Martinez, Alvaro,, Youssef, Lina,, Francesca Crovetto, Lina Youssef, Kalapotharakos, Grigorios, Cristina Paules, Laura Garcia-Otero, Crovetto, Francesca,, Paules, Cristina,, Lund University.   +35 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrauterine Growth Restriction and Doppler Ultrasound [Intrauterin Gelisme Geriligi ve Doppler Ultrasonografi]

Medicine Science, 2016
Intrauterine growth restriction is an important perinatal problem giving rise to increased morbidity and mortality in the growth restricted fetus. Today the aim is to prevent the occurence of intrauterine growth restriction in high risk pregnancies and ...
Senem Arda Duz
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Proteomic analyses in early brain development and neuropathological implications of fetal growth restriction

Neural Regeneration Research
Proteins are the primary functional units within cells, driving complex biological processes essential for stem cell differentiation into specific neural lineages and for the structural and functional maturation of the central nervous system. Advances in
Gemma C. Ventura, Kirat K. Chand, Paul B. Colditz, Julie A. Wixey   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source