Results 31 to 40 of about 140,720 (217)

Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction. [PDF]

PLoS ONE, 2012
BackgroundFetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Silvia Pisaneschi, Francesca A L Strigini, Angel M Sanchez, Silvia Begliuomini, Elena Casarosa, Andrea Ripoli, Paolo Ghirri, Antonio Boldrini, Bruno Fink, Andrea R Genazzani, Flavio Coceani, Tommaso Simoncini   +11 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

IJCM_77A: Predictors of fetal growth restriction in preterm birth

Indian Journal of Community Medicine
Background: Fetal growth restriction (FGR) is defined as fetuses whose estimated fetal weight or abdominal circumference is below the 10th percentile for gestational age.
Ganesh, Suchetha S Rao, Prasanna Mithra, Santosh Rai, Keshava K Pai, Shraddha K Shetty, Sauda, K M Akshaya   +7 more
doaj   +1 more source

The Role of Proteoglycans in Contributing to Placental Thrombosis and Fetal Growth Restriction

Journal of Pregnancy, 2011
Fetal growth restriction is an important pregnancy complication that has major consequences for the fetus and neonate as well as an increased risk of long-term morbidity extending into adulthood.
Joanne M. Said
doaj   +1 more source

Fetal growth restriction in a cohort of migrants in Germany

BMC Pregnancy and Childbirth, 2021
Background Migrant women may have an increased risk of adverse birth outcomes. This study analyses the occurrence of low birth weight, preterm birth and intrauterine growth restriction / fetal growth restriction (IUGR/FGR) in pregnant migrants.
Juliane Ankert, Tanja Groten, Mathias W. Pletz, Sasmita Mishra, Gregor Seliger, Silvia M. Lobmaier, Clarissa Prazeres da Costa, Vera Seidel, Katharina von Weizsäcker, Alexandra Jablonka, Christian Dopfer, Benjamin T. Schleenvoigt   +11 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Prevalence, interactions, determinants and outcomes of low birth weight, small for gestational age and fetal growth restriction among term neonates

BMC Pediatrics
Introduction Small for gestational age and fetal growth restriction are two leading causes for low birth weight in term newborns. Due to the considerable overlap, the exact interactions between these groups have not been adequately studied.
Sangeetha Wickramaratne, Gihan Gunarathna, Eshani Ranasinghe, Hesitha Nimana, Dinuka Kalhara, Sanjeevan Kanagarasa, Shammi Isanka, Tiran Dias, Rasika Herath, Nalin Gamaathige, Sachith Mettananda   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source