Results 291 to 300 of about 922,524 (371)

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination

Advanced Science, EarlyView.
A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang   +6 more
wiley   +1 more source

Willingness to use smart fetal heart rate monitoring devices among pregnant women: an extension of the technology acceptance model. [PDF]

Front Psychol
Wu S, Cui B, Yu X.
europepmc   +1 more source

Simulation of fetal heart rate during hypoxic stress

, 2003
Pedro Sá‐Couto, Willem L. van Meurs, João Bernardes, Joaquim P. Marques de Sá, Jane A. Goodwin   +4 more
openalex   +1 more source

Risk Management in Intrapartum Fetal Monitoring: Accidental Recording of the Maternal Heart Rate [PDF]

, 2010
Hanson, Lisa
core   +1 more source

Dual‐Working‐Pattern Nanosheet‐Based Hydrogel Sensors for Constructing Human‐Machine and Physiological‐Electric Interfaces

Advanced Science, EarlyView.
Hydrogels hold great potential as candidates for next‐generation epidermal electronics; however, an unresolved issue remains: the differentiation and selection of sensing modes in hydrogel sensors. This study integrates series‐parallel conductive nanosheet configurations into an ultra‐soft hydrogel, resulting in enhanced signal intensity and ...
Shitao Shi, Yuanyuan Wang, Zewei Ye, Hongxia Xie, Chencong Liu, Jiaqi Liao, Dawei Zhao, Qingfeng Sun, Julia L. Shamshina, Xiaoping Shen   +9 more
wiley   +1 more source

Suppressed or increased fetal heart rate variability: Which is more associated with intrapartum fetal compromise? [PDF]

Acta Obstet Gynecol Scand
Lear CA, Nakao M, Magawa S, Ikeda T, Gunn AJ.   +4 more
europepmc   +1 more source

Fetal Heart Rate Monitoring [PDF]

Journal of the Royal Society of Medicine, 1989
openaire   +2 more sources

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source