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Unveiling of Placental–Fetal Heart Interplay: A Novel Etiologic and Therapeutic Insight—A Narrative Review [PDF]

Journal of Pregnancy
Congenital heart disease (CHD) is the most common fetal anomaly worldwide. The definite etiology of most CHD is not recognized. A direct genetic etiology is considered for a minority of patients.
Mohsen Shahidi, Arash Pooladi, Yousef Moradi   +2 more
doaj   +2 more sources

Genetic aetiology distribution of 398 foetuses with congenital heart disease in the prenatal setting

ESC Heart Failure, 2023
Aims Copy number variant‐sequencing (CNV‐seq) and exome sequencing (ES) have been used as powerful tools in understanding the role of genetic variants in congenital heart diseases (CHDs).
Tong Yi, Xiaoyan Hao, Hairui Sun, Ye Zhang, Jiancheng Han, Xiaoyan Gu, Lin Sun, Xiaowei Liu, Ying Zhao, Yong Guo, Xiaoxue Zhou, Yihua He   +11 more
doaj   +1 more source

Placental DNA Methylation Abnormalities in Prenatal Conotruncal Heart Defects

Frontiers in Genetics, 2022
Objective: This study aims to characterize the abnormal changes in placental DNA methylation associated with conotruncal heart defects (CTDs) and the level of methylation as epigenetic biomarkers for CTDs detection.Methods: This was a prospective study ...
Jingjing Liu, Jingjing Liu, Yuduo Wu, Yuduo Wu, Hairui Sun, Hairui Sun, Xiaowei Liu, Xiaowei Liu, Xiaoyan Gu, Xiaoyan Gu, Ying Zhao, Ying Zhao, Ye Zhang, Ye Zhang, Jiancheng Han, Jiancheng Han, Yihua He, Yihua He   +17 more
doaj   +1 more source

Genetics and Clinical Features of Noncompaction Cardiomyopathy in the Fetal Population

Frontiers in Cardiovascular Medicine, 2021
Objectives: Noncompaction Cardiomyopathy (NCCM) has been classified as primary genetic cardiomyopathy and has gained increasing clinical awareness; however, little is known about NCCM in the fetal population.
Hairui Sun, Hairui Sun, Hairui Sun, Xiaoyan Hao, Xiaoyan Hao, Xin Wang, Xin Wang, Xiaoxue Zhou, Xiaoxue Zhou, Ye Zhang, Ye Zhang, Xiaowei Liu, Xiaowei Liu, Jiancheng Han, Jiancheng Han, Xiaoyan Gu, Xiaoyan Gu, Lin Sun, Lin Sun, Ying Zhao, Ying Zhao, Tong Yi, Tong Yi, Hongjia Zhang, Hongjia Zhang, Yihua He, Yihua He, Yihua He   +27 more
doaj   +1 more source

Utility of a modified vascular corrosion casting technique in the diagnosis of fetal total anomalous pulmonary venous connection

Scientific Reports, 2021
Total anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiac malformation, and prenatal detection of TAPVC malformation remains a challenging. TAPVC can be easily missed or misdiagnosed in prenatal examinations.
Jiaqi Zhang, Wei Feng, Qiaoyue He, Hongzhi Guo, He Zeng, Ziyi Si, Ya Liu, Yu Wang   +7 more
doaj   +1 more source

Generation of a TIMP3 knockout stem cell line via CRISPR/Cas9 system

Stem Cell Research, 2023
The tissue inhibitors of metalloproteinases 3 (TIMP3) play an essential role in the tumorigenesis of human pancreatic endocrine tumors and Sorsby fundus dystrophy. To further investigate the significance of TIMP3 in disease, we used CRISPR/Cas9 to create
Tong Yi, Jingjing Liu, Siyao Zhang, Yihua He, Jiancheng Han   +4 more
doaj   +1 more source

Whole blood RNA sequencing reveals a differential transcriptomic profile associated with cervical insufficiency: a pilot study

Reproductive Biology and Endocrinology, 2021
Background The uterine cervix is a mechanical and immunological barrier against ascending infection during pregnancy. Cervical insufficiency (CI), a painless cervical dilation that occurs in the mid-trimester, is an important cause of extremely preterm ...
Ga-Hyun Son, So Yeon Choi, Yeon-Ji Ju, Keun-Young Lee, Jae Jun Lee, Ji-Eun Song, Youngmi Kim, Sung Taek Park   +7 more
doaj   +1 more source

Cardiac manifestations in a Chinese cohort of fetuses from mothers with anti-Ro and anti-La antibodies

Frontiers in Pediatrics, 2022
ObjectivesTo analyze the clinical characteristics, echocardiographic features, and prognosis of fetuses based on three groups of cardiac manifestations associated with maternal anti-Ro and anti-La antibodies in China.
Xin Wang, Xiao-wei Liu, Ling Han, Meng-tao Li, Jiu-liang Zhao, Lin Sun, Jian-cheng Han, Xiao-feng Zeng, Xin-ping Tian, Ying Zhao, Yi-hua He   +10 more
doaj   +1 more source

Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt‐induced pulmonary arterial hypertension

ESC Heart Failure, 2022
Aims Although considerable progress has been made in the diagnosis and treatment of congenital heart disease‐associated pulmonary heart hypertension (CHD‐PAH), the clinical prognosis and overall survival of patients with CHD‐PAH remain poor.
Jingjing Zhou
doaj   +1 more source

Case Report of a Triplet Pregnancy with Complete Hydatidiform Mole and Coexisting Twins

Case Reports in Obstetrics and Gynecology, 2022
Background. Triplet pregnancy with complete hydatidiform mole and coexisting twin fetuses is extremely rare with an unknown incidence. Case. Here, we present a case report of a pregnancy with twin fetuses and concurrent hydatidiform mole that resulted in
Marjorie H. Thompson, Nathaniel R. Miller, Shelby L. Haugan, Michael C. Gordon   +3 more
doaj   +1 more source