Results 111 to 120 of about 821,341 (299)
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
Blood, 2015 Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that UNC0638, a selective inhibitor of EHMT1 and EHMT2 histone methyltransferases, induces γ-globin ...
Aline Renneville +10 more
semanticscholar +1 more source
Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression
Nature Genetics, 2021 Li Cheng +14 more
semanticscholar +1 more source
Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin
Journal of Community Hospital Internal Medicine Perspectives, 2018 Fetal Hemoglobin (HbF, α2γ2) is produced from the eighth week of gestation, constitutes 60 – 80 % of total hemoglobin by birth, which is then replaced with adult Hemoglobin A1 (HbA1: α2β2) by 6–12 months. Hereditary Persistence of Fetal Hemoglobin (HPFH)
Irfan Shaukat +4 more
doaj +1 more source
Rapid point-of-care Hemoglobin measurement through low-cost optics and Convolutional Neural Network based validation [PDF]
arXiv, 2017 A low-cost, robust, and simple mechanism to measure hemoglobin would play a critical role in the modern health infrastructure. Consistent sample acquisition has been a long-standing technical hurdle for photometer-based portable hemoglobin detectors which rely on micro cuvettes and dry chemistry. Any particulates (e.g.
arxiv
Blood, 2015 Induction of fetal hemoglobin (HbF) production in adult erythrocytes can reduce the severity of sickle cell disease and β-thalassemia. Transcription of β-globin genes is regulated by the distant locus control region (LCR), which is brought into direct ...
I. Krivega +6 more
semanticscholar +1 more source
Magnetic mechanism for the biological functioning of hemoglobin [PDF]
arXiv, 2019 The role of magnetism in the biological functioning of hemoglobin has been debated since its discovery by Pauling and Coryell in 1936. The hemoglobin molecule contains four heme groups each having a porphyrin layer with a Fe ion at the center. Here, we present combined density-functional theory and quantum Monte Carlo calculations for an effective ...
arxiv
Clinical Chemistry, 1992 Abstract We report microchromatographic measurement of fetal hemoglobin (HbF) proportions in a 36-year-old African-American multigravida woman. At 34 weeks she delivered a 630-g male infant who subsequently did well. Hemoglobin electrophoresis of the hemolysate revealed nearly 100% HbF without HbA, an extremely unusual naturally ...
C. G. Pantazis +3 more
openaire +3 more sources
Blood, 2015 Inhibition of lysine-specific demethylase 1 (LSD1) has been shown to induce fetal hemoglobin (HbF) levels in cultured human erythroid cells in vitro. Here we report the in vivo effects of LSD1 inactivation by a selective and more potent inhibitor, RN-1 ...
Shuaiying Cui +14 more
semanticscholar +1 more source
HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]
, 2017 Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core
Epigenetic modulations on the fetal hemoglobin induction [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2012 In recent years of experience fetal hemoglobin (HbF) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches.
Najmaldin Saki +4 more
doaj +2 more sources