Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression. [PDF]
Krause BJ +12 more
europepmc +1 more source
Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao +11 more
wiley +1 more source
Prenatal Delivery of HIF-1α siRNA Using Transferrin-Modified Lipid Nanoparticles Alleviates Hypoxia-Induced Neurodevelopmental Abnormalities via PTEN/PI3K/AKT Signaling. [PDF]
Du F +6 more
europepmc +1 more source
Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare +7 more
wiley +1 more source
Are pulmonary neuroepithelial bodies sensors for acute airway hypoxia implicated in the central regulation of breathing? [PDF]
Brouns I +7 more
europepmc +1 more source
Abstract Objective To evaluate whether a rule‐based artificial intelligence (AI) program can enhance interrater agreement in cardiotocography (CTG) interpretation between nurse–midwives and obstetricians. Methods CTG data from 50 singleton pregnancies at ≥32 weeks of gestation were used to develop a rule‐based AI program based on National Institute of ...
Sriwipa Kaewsrinual +4 more
wiley +1 more source
Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart. [PDF]
William W +5 more
europepmc +1 more source
Urethral injury during vaginal delivery: Incidence, management and long‐term outcomes
Abstract Objective This study examines the incidence, obstetric risk factors, surgical management, and long‐term outcomes of obstetric‐associated urethral injuries during vaginal deliveries. Methods A retrospective case series was conducted at a single, tertiary university‐affiliated medical center between January 2018 and December 2023.
Yoav Baruch +5 more
wiley +1 more source

