Results 281 to 290 of about 850,904 (382)
Mucosal‐associated invariant T cells in rheumatic diseases.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek+7 more
wiley +1 more source
Near-Term Fetal Hypoxia–Ischemia in Rabbits
Alexander Drobyshevsky+7 more
openalex +1 more source
Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage
ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu+8 more
wiley +1 more source
Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
The comparative effects of Doxorubicin and Aloe vera on HepG2 spheroids grown in a microfluidic device are illustrated in the graphical abstract. In the upper panel, red markers indicate that Doxorubicin treatment primarily induces necrosis in the spheroids.
Atakan Tevlek+2 more
wiley +1 more source
Redox Imbalance Is Associated with Neuronal Apoptosis in the Cortex of Neonates Gestated Under Chronic Hypoxia. [PDF]
Figueroa EG+8 more
europepmc +1 more source
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu+9 more
wiley +1 more source
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao+12 more
wiley +1 more source
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy
Andrew D. Kane+8 more
openalex +2 more sources