Results 61 to 70 of about 850,904 (382)

Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]

, 2009
The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
A Malassine, AC Epstein, AM Carter, AM Zafari, Anne E Chambers, AP MacKay, BJ Hawkins, C Moser, C Peyssonnaux, CW Redman, D Berg, D Gerald, DS Hoffmann, DS Tannetta, EL Bell, EL Pagé, FX Yi, GL Semenza, H Pelicano, Harpal Randeva, I Thaler, J Golab, J Sugawara, JA Martin, K Kanasaki, L Duley, L Wood, M Geiszt, M Ushio-Fukai, M Wang, N Kanayama, NS Chandel, P Huang, PH Maxwell, R Dworakowski, R Pijnenborg, RD Martin, RK Bruick, RW Redline, S Banerjee, S Lamond, S Melov, S Muzaffar, S Nemoto, SL Adamson, Subhasis Banerjee, T Cramer, T Torbergsen, Y Liu, Y Pan, Y Wang, YA Suh   +51 more
core   +4 more sources

Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy

Advanced Science, 2022
Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying
Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison   +13 more
doaj   +1 more source

Induction of controlled hypoxic pregnancy in large mammalian species. [PDF]

, 2015
Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar to those measured in human pregnancy complicated by ...
Allison, Beth J, Brain, Kirsty L, Cross, Christine M, Giussani, Dino A, Herrera, Emilio A, Itani, Nozomi, Kane, Andrew D, Niu, Youguo   +7 more
core   +2 more sources

Fetal Hypoxia Results in Programming of Aberrant Angiotensin II Receptor Expression Patterns and Kidney Development [PDF]

International Journal of Medical Sciences, 2013
AIMS: The present study tested the hypothesis that fetal hypoxia adversely affects kidney development in fetal and offspring rats and alter the expression patterns of angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors.
Pablo J. Gonzalez‐Rodriguez, Wenni Tong, Xue Qin, Yong Li, Shirley Hu, Li Zhang   +5 more
openalex   +2 more sources

How does fetal inflammatory response syndrome change fetal response to hypoxia? An experimental study in a fetal sheep model

Acta Obstetricia et Gynecologica Scandinavica
Introduction Fetal inflammatory response syndrome associated with acidosis during labor is a high‐risk situation for the fetus. This study evaluated hemodynamic, gasometric, and heart rate variability changes during acute fetal inflammatory response ...
Geoffroy Chevalier, Charles Garabedian, Valeria De Stephano, Anne Wojtanowski, Yasmine Ould Hamoud, Louis Galan, Dyuti Sharma, Kevin Le Duc, Julien De Jonckheere, Laurent Storme, Guillemette Marot, Louise Ghesquière   +11 more
doaj   +1 more source

Mechanism of development of pre-eclampsia linking breathing disorders to endothelial dysfunction [PDF]

, 2009
High blood pressure is an important component of pre-eclampsia. The underlying mechanism of development of hypertension in pre-eclampsia is complicated and still remains obscure.
Barnes, Vernon A., Fadel, Hossam E., Ravinder, Jerath   +2 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus

Scientific Reports, 2017
Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain.
Miguel A. Zarate, Michelle D. Rodriguez, Eileen I. Chang, Jordan T. Russell, Thomas J. Arndt, Elaine M. Richards, Beronica A. Ocasio, Eva Aranda, Elizabeth M. Gordon, Kevin Yu, Josef Neu, Maureen Keller-Wood, Eric W. Triplett, Charles E. Wood   +13 more
doaj   +1 more source

A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]

, 2012
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Reitter, Anke, Yuan, Juping   +4 more
core   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source