Results 51 to 60 of about 110,385 (298)
Fetal Cerebrovascular Maturation: Effects of Hypoxia [PDF]
Seminars in Pediatric Neurology, 2018 The human cerebral vasculature originates in the fourth week of gestation and continues to expand and diversify well into the first few years of postnatal life. A key feature of this growth is smooth muscle differentiation, whereby smooth muscle cells within cerebral arteries transform from migratory to proliferative to synthetic and finally to ...
openaire +2 more sources
, 2002 Background - The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management.
Gardner, David S. +2 more
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Adjunctive technologies for intrapartum fetal monitoring: current perspectives and proof of concept for a novel approach [PDF]
, 2023 Fetal monitoring is a recurring theme in perinatal morbidity and mortality reports, highlighting the limitations of cardiotocography and current adjunctive technologies, such as fetal blood sampling (FBS). There is an unmet need for more robust methods
Brown, Andrew Patrick
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Fetal hypoxia in labor. Treatment methods [PDF]
, 2022 Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Hipoxia fetală este o cauză importanta a deceselor neonatale ocupând aproximativ 23 % din structura mortalității perinatale.
Nistor, Veronica
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity
BMJ Open Diabetes Research & Care, 2020 Introduction The hemochorial placenta provides a critical barrier at the maternal–fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus.
Jackson Nteeba +5 more
doaj +1 more source
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia [PDF]
, 2015 Artículo de publicación ISIExperimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction.
Botting, Kimberley J. +13 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source