Results 71 to 80 of about 3,153,630 (372)

Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode? [PDF]

, 2006
Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection.
Agarwal A., Agrawal Y., Aumuller G., Bacher M., Bacher M., Bernhagen J., Bloom B.R., Bove S.E., Bronson R.A., Calandra T., Calandra T., Calandra T., Calne R.Y., Choufani G., Cooper T.G., Cropp C.S., David J.R., Eickhoff R., Eickhoff R., F. Sinowatz, Frenette G., Frenette G., Frenette G., G. Hoffbauer, G. Jennemann, Goyal H.O., H. Kaltner, H.-J. Gabius, Hoffer A.P., Howards S.S., Hudson J.D., J. Seitz, Kaltner H., Kaunisto K., Kirchhoff C., Kirchhoff C., Kleemann R., Legendre H., M.-P. Schüring, Manin M., Meinertz H., Meinhardt A., Meinhardt A., R. Eickhoff, Rosengren E., Seitz J., Steinhoff M., Sullivan R., Sun H.W., Suzuki M., Wada S., Wada S., Waeber G., Weiser W.Y., Wilhelm B., Zeng F.Y., Zeng F.Y., Zeng F.Y.   +57 more
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

Frontiers in Pediatrics, 2021
Background: While physiologically based pharmacokinetic (PBPK) models generally predict pharmacokinetics in pregnant women successfully, the confidence in predicting fetal pharmacokinetics is limited because many parameters affecting placental drug ...
Xiaomei I. Liu, Dionna J. Green, John N. van den Anker, Natella Y. Rakhmanina, Natella Y. Rakhmanina, Homa K. Ahmadzia, Jeremiah D. Momper, Kyunghun Park, Gilbert J. Burckart, André Dallmann   +9 more
doaj   +1 more source

Comparison of LPS-stimulated release of cytokines in punch versus transwell tissue culture systems of human gestational membranes [PDF]

, 2010
Background Cytokine signaling within the amnionic, chorionic and decidual extraplacental gestational membranes plays an important role in membrane rupture and the timing of birth.
Loch-Caruso, Rita, Miller, Mark F.
core   +4 more sources

Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research.

Current pharmaceutical design, 2017
Preterm birth (PTB) is clinically defined as process of giving birth before 37 weeks of gestation and is a leading cause of death among neonates and children under the age of five.
J. Gnecco, Anjali P. Anders, D. Cliffel, V. Pensabene, L. Rogers, K. Osteen, D. Aronoff   +6 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Premature Rupture of Membranes and Severe Weather Systems

Frontiers in Physiology, 2020
There has long been anecdotal evidence of early labor and delivery in severe weather events leading to preterm birth. In particular, significant barometric pressure changes are associated with hurricanes and bomb cyclones. Some authors have related these
Mackenzie L. Wheeler, Michelle L. Oyen
doaj   +1 more source

Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions

BMC Pregnancy and Childbirth, 2016
BackgroundPreterm premature rupture of membranes (PPROM) is the largest identifiable cause of preterm birth. There is currently no good screening test for PPROM in low-risk asymptomatic patients.
V. Nunes, J. Cross, J. Speich, D. R. Morgan, J. Strauss, R. Ramus   +5 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Modern concept of physiological signaling systems in cattle fetuses with the participation of FC-γ-receptors

Theoretical and Applied Veterinary Medicine, 2021
The article presents a literature review on the modification of expression and recycling of Fc-γ-receptors of fetal jejunal enterocytes in cattle. Based on the analyzed data, a modern concept of physiological signaling systems in cattle fetuses with the ...
D. M. Masіuk
doaj   +1 more source