Results 71 to 80 of about 2,436,052 (292)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes.

PLoS ONE, 2012
BackgroundRupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS) and senescence.
Ramkumar Menon, Jie Yu, Patrice Basanta-Henry, Lina Brou, Sarah L Berga, Stephen J Fortunato, Robert N Taylor   +6 more
doaj   +1 more source

pH2B-eGFP expression from Model II 42 day fetal chorionic membrane.

, 2017
Fluorescence microscopy of OCT embedded fetal-maternal chorionic interphase at 42 days of gestation, showing 10x magnification for bright field, DAPI, GFP and DAPI + GFP. pH2B-eGFP expression is confined to the fetal side of fetal membrane.
Jeff Sommer (3635998), Renan B. Sper (3635989), Jorge A. Piedrahita (278619), Sehwon Koh (3636001), Bruce Collins (3635992), Ignacio Caballero (290123), Xia Zhang (41398), Sean Simpson (3635983), Robert M. Petters (3635986), Jeff L. Platt (3635995)   +9 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Membrane fouling in osmotically driven membrane processes: A review

, 2016
The utilization of osmosis for engineered applications sparked off various emerging technologies relying on osmotically driven membrane processes (ODMPs).
Fane, Anthony Gordon, Tang, C, She, Q, Wang, Rong, She, Qianhong, Tang, Chuyang Y., Wang, R, Fane, AG   +7 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Fetal electrocardiogram: ST waveform analysis in intrapartum surveillance [PDF]

, 2007
ST waveform analysis of fetal electrocardiogram (ECG) for intrapartum surveillance (STAN) is a newly introduced method for fetal surveillance. The purpose of this commentary is to assist in the proper use of fetal ECG in combination with cardiotocography
I Amer‐Wahlin, S Arulkumaran, Marsál, K, H Hagberg, Hagberg, H, GHA Visser, Visser, GH, Arulkumaran, S., Visser, G. H. A., Amer-Wåhlin, Isis,, Marsal, Karel,, Amer-Wåhlin, Isis, K Maršál, Marsal, Karel, Arulkumaran, S, Amer-Wahlin, I, Lund University., Visser, GHA, Hagberg, H.   +18 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes.

PLoS ONE, 2014
ObjectiveSpontaneous preterm birth (PTB) and preterm prelabor rupture of membranes (pPROM) are major pregnancy complications often associated with a fetal inflammatory response.
Sarah Bredeson, John Papaconstantinou, James H Deford, Talar Kechichian, Tariq A Syed, George R Saade, Ramkumar Menon   +6 more
doaj   +1 more source