Results 141 to 150 of about 35,483 (274)

The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post‐Myocardial Infarction

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
Following myocardial infarction, MCPIP1 deficiency in macrophages triggers ferroptosis, driving proinflammatory M1 dominance over reparative M2 phenotypes. This imbalance amplifies splenic monocyte release and sustains cardiac inflammation. Concurrently, excessive inflammatory mediators and insufficient TGF‐β impair fibroblast activation, delaying ...
Xingxu Zhang   +8 more
wiley   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li   +11 more
wiley   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao   +18 more
wiley   +1 more source

Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
Improved reactive oxygen species scavenging capacities of functionalized micro/nanorobots (MNRs) are useful for the treatment of inflammatory bowel disease (IBD). MNRs can break the harmful bacteria in IBD, thereby eliminating inflammation and restoring the intestinal barrier function.
Ying Feng   +5 more
wiley   +1 more source

Incidence and risk factors of early-onset neonatal infections in Butembo: case of Katwa Health Zone from January 2020 to December 2022. [PDF]

open access: yesBMC Pediatr
Saasita A   +8 more
europepmc   +1 more source

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health

open access: yesBioEssays, Volume 47, Issue 7, July 2025.
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar   +4 more
wiley   +1 more source

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