Results 41 to 50 of about 35,483 (274)

Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells

Frontiers in Physiology, 2020
Preterm premature rupture of membranes is a leading cause of preterm births. Cytokine induced matrix metalloproteinase1 and interleukin 8 production from amnion mesenchymal cells may contribute to fetal membrane weakening and rupture.
William Marinello, Liping Feng, Terrence K. Allen   +2 more
doaj   +1 more source

Human Fetal Membranes: Their Preterm Premature Rupture1 [PDF]

Biology of Reproduction, 2000
At the 1999 annual meeting of the Society for the Study of Reproduction there were three speakers in the minisymposium entitled "I've got to get out of here: fetal-maternal interactions involved in parturition". The primary focus was on research progress in understanding the mechanisms involved in human parturition.
Gillian D. Bryant-Greenwood, Lynnae K. Millar   +1 more
openaire   +3 more sources

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

A collagen plug with shape memory to seal iatrogenic fetal membrane defects after fetoscopic surgery

Bioactive Materials, 2023
Iatrogenic preterm premature rupture of fetal membranes (iPPROM) after fetal surgery remains a strong trigger for premature birth. As fetal membrane defects do not heal spontaneously and amniotic fluid leakage and chorioamniotic membrane separation may ...
Rob T.C. Meuwese, Elly M.M. Versteeg, Joris van Drongelen, Daniëlle de Hoog, Debora Bouwhuis, Frank P.H.A. Vandenbussche, Toin H. van Kuppevelt, Willeke F. Daamen   +7 more
doaj  

Maternal and fetal outcome in preterm premature rupture of membrane

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2021
Background: The objective was to study the maternal and fetal outcome in women with premature rupture of membranes.Methods: It was a prospective analytic hospital based study, study population include 100 obstetrics cases of singleton pregnancy with gestational age of 28 week to 36 week with spontaneous rupture of membranes over a period of 2 years ...
Mamta Sharma, Monika Agrwal, Hemavati Goudappagoudra   +2 more
openaire   +3 more sources

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

The diagnostic value of the lactate concentration in the vaginal fluid for diagnosis of premature rupture of membranes

Armaghane Danesh Bimonthly Journal, 2013
Background & aim: Accurate and timely diagnosis of premature rupture of fetal membranes has a major role in reducing infant and mother mortality and morbidity .The purpose of this study was to determine the diagnostic value of the lactate concentration ...
N Nazari, M Ahmadi, M Mazani, H Alavimajd, M Refaei, M Hedayati   +5 more
doaj  

Predictors of Premature Rupture of Membranes among Pregnant Women in Rural Uganda: A Cross-Sectional Study at a Tertiary Teaching Hospital

International Journal of Reproductive Medicine, 2020
Background Premature rupture of membranes (PROM) is a common condition in developed and developing countries and poses a serious threat to the maternal and fetal well-being if not properly managed.
Simon Byonanuwe, Emmanuel Nzabandora, Baltazar Nyongozi, Theophilus Pius, D. Ayebare, Collins Atuheire, Wilson Mugizi, M. Nduwimana, Maxwell Okello, Y. Fajardo, R. Ssebuufu   +10 more
semanticscholar   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Factors influencing the abortion interval of second trimester pregnancy termination using misoprostol

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objectives: To determine the factors influencing the abortion interval (AI) for medical termination of second-trimester pregnancy using misoprostol. Materials and Methods: All patients who were admitted for second-trimester pregnancy termination between ...
Wan-Hua Ting, Fu-Hsiang Peng, Ho-Hsiung Lin, Hsin-Fen Lu, Sheng-Mou Hsiao   +4 more
doaj   +1 more source