Results 91 to 100 of about 409,457 (297)

Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster

Journal of Lipid Research, 2001
The fetus obtains a significant amount of cholesterol from de novo synthesis. Studies have suggested that maternal cholesterol may also contribute to the cholesterol accrued in the fetus. Thus, the present studies were completed to determine whether diet-
Julie A. McConihay, Paul S. Horn, Laura A. Woollett   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stem Cells from Fetal Membranes

, 2008
Stem cells that can be derived from fetal membranes represent an exciting field of research that bears tremendous potential for developmental biology and regenerative medicine.
Hemberger, M., Tanaka, S., Natale, D., Yang, W., Brown, Thomas L., Dunk, C., Gargett, C. E.   +6 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes

, 2014
Problem The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in fetal membranes from spontaneous
Polettini, Jossimara, Menon, Ramkumar, Saade, George R., Boldogh, Istvan, Polettini, Jossimara [UNESP], Syed, Tariq Ali   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Antimicrobial proteins and peptides in pregnancy: Guardians of the maternal–fetal frontier

Frontiers in Immunology
The success of human pregnancy relies on the precise synchronization and adaptation of the maternal immune system, which, together with fetal tissues, establishes a tolerogenic intrauterine environment while maintaining the capacity to mount effective ...
Andrea Olmos-Ortiz, Bruno Rivas-Santiago, Oscar González-Muñíz, Daniel Ortuño-Sahagún, Ismael Mancilla-Herrera, Cecilia Helguera-Repetto, Verónica Zaga-Clavellina   +6 more
doaj   +1 more source

Effect of twin pregnancy chorionic properties on maternal and fetal outcomes

Taiwanese Journal of Obstetrics & Gynecology, 2018
Objective: This study aimed to determine the effect of twin pregnancy chorionic properties on pregnancy complications and fetal outcomes. Materials and methods: A total of 559 subjects with gemellary pregnancy were included in the retrospective analysis,
Bibo Feng, Jianjun Zhai, Yu Cai
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Programmed Fetal Membrane Senescence and Exosome-Mediated Signaling: A Mechanism Associated With Timing of Human Parturition

Frontiers in Endocrinology, 2017
Human parturition is an inflammatory process that involves both fetal and maternal compartments. The precise immune cell interactions have not been well delineated in human uterine tissues during parturition, but insights into human labor initiation have
Ramkumar Menon, Sam Mesiano, Robert N. Taylor   +2 more
doaj   +1 more source