Leveraging bioengineering to assess cellular functions and communication within human fetal membranes [PDF]
Journal of Maternal-Fetal and Neonatal Medicine, 2022 The fetal membranes enclose the growing fetus and amniotic fluid. Preterm prelabor rupture of fetal membranes is a leading cause of preterm birth. Fetal membranes are composed of many different cell types, both structural and immune.
Virginia Pensabene +2 more
exaly +3 more sources
Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]
Reproductive Biology and Endocrinology, 2004 Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter +5 more
doaj +2 more sources
Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair. [PDF]
Int J Mol SciThe human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve ...
Rouzaire M +3 more
europepmc +2 more sources
A collagen plug with shape memory to seal iatrogenic fetal membrane defects after fetoscopic surgery
Bioactive Materials, 2023 Iatrogenic preterm premature rupture of fetal membranes (iPPROM) after fetal surgery remains a strong trigger for premature birth. As fetal membrane defects do not heal spontaneously and amniotic fluid leakage and chorioamniotic membrane separation may ...
Rob T.C. Meuwese +7 more
doaj +1 more source
The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth. [PDF]
PLoS ONE, 2014 Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection.
Carrington J Morwood, Martha Lappas
doaj +1 more source
Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells
Biomolecules, 2022 Nuclear-factor-E2-related factor 2 (Nrf2) is a key transcription factor for the regulation of cellular responses to cellular stress and inflammation, and its expression is significantly lower after spontaneous term labor in human fetal membranes ...
Justin Gary Padron +3 more
doaj +1 more source
mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes? [PDF]
Int J Mol Sci, 2023 Clinically, unique markers in fetal membrane cells may contribute to the search for biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood.
Mikkelsen E +9 more
europepmc +2 more sources
Effect of silibinin in reducing inflammatory pathways in in vitro and in vivo models of infection-induced preterm birth. [PDF]
PLoS ONE, 2014 Infection-induced preterm birth is the largest cause of infant death and of neurological disabilities in survivors. Silibinin, from milk thistle, exerts potent anti-inflammatory activities in non-gestational tissues.
Ratana Lim +3 more
doaj +1 more source
Frontiers in Physiology, 2020 IntroductionSpontaneous preterm birth (sPTB), which predominantly presents as spontaneous preterm labor (sPTL) or prelabor premature rupture of membranes (PPROM), is a syndrome that accounts for 5–10% of live births annually.
Jing Pan +3 more
doaj +1 more source
Differing Prevalence and Diversity of Bacterial Species in Fetal Membranes from Very Preterm and Term Labor [PDF]
, 2009 Background: Intrauterine infection may play a role in preterm delivery due to spontaneous preterm labor (PTL) and preterm prolonged rupture of membranes (PPROM). Because bacteria previously associated with preterm delivery are often difficult to culture,
Malika Azizia +15 more
core +2 more sources