Results 51 to 60 of about 1,114,562 (247)

Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes [PDF]

, 2013
BACKGROUND: Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition.
Lappas, M, Walker, SP, Riley, C, Rice, GE, Chai, M, Permezel, M   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Preterm and premature rupture of fetal membranes

Ginekologia Polska
Premature rupture of fetal membranes (PRFM) is rupture of fetal membranes before onset of labor (pre-labor) and after 37 gestational weeks. Preterm premature rupture of fetal membranes (PPRFM) is rupture of fetal membranes before 37 gestational weeks ...
Svetlana Shikanova, Ibrahim A. Abdelazim, Ayagoz Nurmagambetova, Altynay Kabdygaliyeva   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome

Frontiers in Immunology, 2020
Context and Objectives: Inflammation is the leading mechanism involved in both physiological and pathological rupture of fetal membranes. Our aim was to obtain a better characterization of the inflammasome-dependent inflammation processes in these ...
Marilyne Lavergne, Corinne Belville, Héléna Choltus, Christelle Gross, Régine Minet-Quinard, Régine Minet-Quinard, Denis Gallot, Denis Gallot, Vincent Sapin, Vincent Sapin, Loïc Blanchon   +10 more
doaj   +1 more source

RAGE and HMGB1 expressions in fetal membranes of premature rupture of membranes patients

, 2022
BACKGROUND Premature rupture of membranes (PROM) often occurs in pregnancy. The fetal membrane weakening is caused by inflammation involving receptor activation for advanced glycation end-products (RAGE) and high mobility group box protein 1 (HMGB1). The
Sudiarta, Ketut Edy, Rahadianto, Candra, Cindy Jennilyn, Handajani, Fitri, Khan, Joan   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Anti-inflammatory Elafin in human fetal membranes

, 2017
Objective:Elafin is a low molecular weight protein with antileukoproteinase, anti-inflammatory, antibacterial and immunomodulating properties. The profile of Elafin in fetal membranes is not well characterized. This study determined the changes in Elafin
Jossimara Polettini, Menon, Ramkumar, Bo Jacobsson, Nathalia Noda, Noda, Nathalia [UNESP], Jacobsson, Bo,, Stalberg, Cecilia, Noda, Nathalia, Polettini, Jossimara, Cecilia Stalberg, Jacobsson, Bo, Ramkumar Menon, Polettini, Jossimara [UNESP]   +12 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Clinical and Histologic Evaluation of the Hysterotomy Site and Fetal Membranes after Open Fetal Surgery for Fetal Spina Bifida Repair [PDF]

, 2019
INTRODUCTION Among the risks associated with open fetal surgery, myometrium and fetal membrane issues are vexing problems since they may lead to uterine dehiscence or preterm premature rupture of membranes resulting in uterine rupture or preterm birth ...
Ochsenbein-Kölble, Nicole, Zimmermann, Roland, Krähenmann, Franziska, Brandt, Simone, Meuli, Martin, Hüsler, Margaret, Mazzone, Luca, Möhrlen, Ueli, Bode, Peter, Mazzone L, Krähenmann F, Hüsler M, Zimmermann R, Bode P, Brandt S, Ochsenbein-Kölble N, Meuli M, Möhrlen U   +17 more
core   +1 more source