Results 61 to 70 of about 409,457 (297)

Clinical and Histologic Evaluation of the Hysterotomy Site and Fetal Membranes after Open Fetal Surgery for Fetal Spina Bifida Repair [PDF]

, 2019
INTRODUCTION Among the risks associated with open fetal surgery, myometrium and fetal membrane issues are vexing problems since they may lead to uterine dehiscence or preterm premature rupture of membranes resulting in uterine rupture or preterm birth ...
Ochsenbein-Kölble, Nicole, Zimmermann, Roland, Krähenmann, Franziska, Brandt, Simone, Meuli, Martin, Hüsler, Margaret, Mazzone, Luca, Möhrlen, Ueli, Bode, Peter   +8 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Anti-inflammatory Elafin in human fetal membranes

, 2017
Objective:Elafin is a low molecular weight protein with antileukoproteinase, anti-inflammatory, antibacterial and immunomodulating properties. The profile of Elafin in fetal membranes is not well characterized. This study determined the changes in Elafin
Jossimara Polettini, Menon, Ramkumar, Bo Jacobsson, Nathalia Noda, Noda, Nathalia [UNESP], Jacobsson, Bo,, Stalberg, Cecilia, Noda, Nathalia, Polettini, Jossimara, Cecilia Stalberg, Jacobsson, Bo, Ramkumar Menon, Polettini, Jossimara [UNESP]   +12 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fetal Portal System Flowmetry and Intra-Amniotic Inflammation in Preterm Prelabor Rupture of Membranes

, 2019
To determine the pulsatility index (PI) in the fetal splenic vein, the main portal vein, the left portal vein, and the ductus venosus with respect to the presence or absence of intra-amniotic inflammation (IAI) in preterm prelabor rupture of membranes ...
Kacerovsky, Marian, Stranik, Jaroslav, Spacek, Richard, Musilova, Ivana, Jacobsson, Bo,   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial) [PDF]

, 2009
BACKGROUND: At present, women with threatened preterm labor before 32 weeks of gestation are, after transfer to a perinatal center, treated with tocolytics and corticosteroids. Many of these women are treated unnecessarily.
van Pampus Maria G, Femke F Wilms, Wilms, Femke F., Scherjon Sicco A, Derks Jan B, Bolte, A.C. (Annemieke), Van der Post, JAM, Sollie, K.M. (Krystyna), Bolte, AC, Lotgering, F.K. (Fred), Lotgering, F.K., Spaanderman, M, Lotgering, FK (Fred), van Eyck, J., Bloemenkamp Kitty WM, Post, J.A. van der, Bolte, Annemiek C., van Pampus, M.G., Vis, JY, Willekes, C, Vis, J.Y., van Pampus, Marielle, Wilms, FF, Annemiek C Bolte, Eyck, J. (Jim) van, Johannes J Duvekot, Scheepers, Liesbeth C. J., Bloemenkamp, KWM, Oudijk, Martijn A., Duvekot Johannes J, Duvekot, Johannes J., Cornette, J., Bloemenkamp, K.W.M. (Kitty), van der Post, Joris A. M., Kwee, Anneke, Mol, BWJ (Ben), Opmeer, B.C., Willekes Christine, Jérôme Cornette, Krystyna M Sollie, Christine Willekes, Spaanderman Marc EA, Kwee, A., Spaanderman, M.E., Wilms, F.F., Sollie, K.M., Scheepers Hubertina CJ, Bolte, A.C., Willekes, C., Ben Willem J Mol, Opmeer Brent C, Lotgering, Fred K., van Eyck, J, van Pampus, MG, van Eyck Jim, Martina M Porath, Scheepers, H.C., Kwee, A. (Anneke), Vis Jolande Y, Scheepers, Hubertina C. J., Porath, MM, Sicco A Scherjon, Pampus, M.G. (Maria) van, Kwee Anneke, Post, J.A.M. (Joris) van der, Wilms, F.F. (Femke), Porath, M. (Martina), Pampus, M.G. van, Scherjon, Sicco A., Opmeer, BC, Eyck, J. van, Sollie, KM, Derks, J.B. (Jan), Porath, Martina M., Cornette Jérôme, Vis, J.Y. (Jolande), Mol, B.W., Bolte Annemiek C, Jim van Eyck, Marc EA Spaanderman, Scherjon, S.A., Hubertina CJ Scheepers, Jolande Y Vis, Kitty WM Bloemenkamp, Mol Ben, Bloemenkamp, Kitty W. M., van der Post, J.A., Scheepers, H.C.J., van Eyck, Jim, Opmeer, Brent C., Porath Martina M, Martijn A Oudijk, Scheepers, HC, Wilms Femke F, Derks, J.B., Spaanderman, Marc E. A., Cornette, JMJ, Fred K Lotgering, van Pampus, Maria G., Bloemenkamp, K.W., Scheepers, H.C.J. (Hubertina), Anneke Kwee, Willekes, Christine, Opmeer, B.C. (Brent), Oudijk, MA, Duvekot, J.J. (Hans), Sollie, Krystyna M., Oudijk, M.A. (Martijn), Cornette, J.M.J. (Jérôme), van der Post Joris AM, Duvekot, J.J., Scherjon, SA, Oudijk, M.A., Mol, Ben Willem J., Sollie Krystyna M, Derks, JB, Lotgering Fred K, Brent C Opmeer, Oudijk Martijn A, Scherjon, S.A. (Sico), Kwee, A, Willekes, C. (Christine), Porath, M.M., Joris AM van der Post, Maria G van Pampus, Cornette, Jerome, Duvekot, JJ, Spaanderman, M.E.A., Jan B Derks, Derks, Jan B., Mol, B.W.J. (Ben), Vis, Jolande Y.   +131 more
core   +1 more source

c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation

Frontiers in Cell and Developmental Biology
Background: Intra-amniotic inflammation (IAI) is associated with increased risk of preterm birth and bronchopulmonary dysplasia (BPD), but the mechanisms by which IAI leads to preterm birth and BPD are poorly understood, and there are no effective ...
April W. Tan, Xiaoying Tong, Silvia Alvarez-Cubela, Pingping Chen, Aline Guimarães Santana, Alejo A. Morales, Runxia Tian, Rae Infante, Vanessa Nunes de Paiva, Shathiyah Kulandavelu, Shathiyah Kulandavelu, Merline Benny, Juan Dominguez-Bendala, Shu Wu, Karen C. Young, Claudia O. Rodrigues, Claudia O. Rodrigues, Claudia O. Rodrigues, Augusto F. Schmidt   +18 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source