Results 101 to 110 of about 349,291 (334)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Intrapartum Fetal Heart Rate: A Possible Predictor of Neonatal Acidemia and APGAR Score

Frontiers in Physiology, 2018
Background: Predicting perinatal outcomes based on patterns of fetal heart rate (FHR) remains a challenge. The aim of this study was to evaluate intrapartum FHR variability as predictor for neonatal acidemia and APGAR score.Methods: This was a ...
Thâmila Kamila de Souza Medeiros, Thâmila Kamila de Souza Medeiros, Mirela Dobre, Daniela Monteiro Baptista da Silva, Daniela Monteiro Baptista da Silva, Andrei Brateanu, Ovidiu Constantin Baltatu, Ovidiu Constantin Baltatu, Luciana Aparecida Campos, Luciana Aparecida Campos   +9 more
doaj   +1 more source

Rh Negative Status and Isoimmunization Update: A Case-Based Approach to Care [PDF]

, 2003
Prior to the 1970s and the advent of Rho (D) immune globulin (RIG) for Rh negative women, hemolytic disease of the newborn led to morbidity, long-term disabilities, and mortality.
Hanson, Lisa, Harrod, Kathryn Shisler, Heywood, Patricia, VandeVusse, Leona   +3 more
core   +1 more source

Analysis of factors influencing the ultrasonic fetal weight estimation [PDF]

, 2008
Objective: The aim of our study was the evaluation of sonographic fetal weight estimation taking into consideration 9 of the most important factors of influence on the precision of the estimation. Methods: We analyzed 820 singleton pregnancies from 22 to
Alexander Strauss, Barnhard Y, Baum JD, Ben-Aroya Z, Benacerraf BR, Blann DW, Blickstein I, Bottoms SF, Carolin Kü, Chauhan SP, Chuang L, Davis RO, Deter RL, Divon MY, Dudley NJ, Edwards A, Farrell T, Ferrero A, Field NT, Hadlock FP, Hadlock FP, Hellmeyer L, Hill LM, Honarvar M, Ivo Markus Heer, Jouannic JM, Kaaij MW, Luke B, Martin Dugas, Medchill MT, Merz E, Meyer WJ, Mills MD, Mongelli M, Mongelli M, Moore TR, Nadin Vö, Nzeh DA, O'Keeffe DF, Owen P, Patterson RM, Predanic M, Pressman EK, Rossavik IK, Scott F, Shamley KT, Shepard MJ, Smith GC, Snijders RJ, Spinnato JA, Susanne Mü, Toohey JS, Townsend RR, Valea FA, Warsof SL, Wong SF, Zador IE   +56 more
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Diagnóstico matemático de la monitoría fetal con la Ley de Zipf-Mandelbrot y la teoría de los sistemas dinámicos aplicados a la fisiología cardiaca Mathematical diagnosis of fetal monitoring using the Zipf-Mandelbrot law and dynamic systems’ theory applied to cardiac physiology

Revista Colombiana de Obstetricia y Ginecología, 2006
Objetivo: desarrollar un diagnóstico matemático de la monitoría fetal a partir de la aplicación de la ley de Zipf-Mandelbrot y las concepciones de salud y enfermedad de los sistemas dinámicos a la aparición de Componentes Dinámicos del Sistema (CDS) en ...
Rodríguez Javier, Prieto Signed, Liliana Ortiz, Alejandro Bautista, Luisa Álvarez, Catalina Correa, Nicolás Avilán   +6 more
doaj  

Robust estimation of fetal heart rate from US Doppler signals [PDF]

, 2009
International audienceIn utero, Monitoring of fetal wellbeing or suffering is today an open challenge, due to the high number of clinicalparameters to be considered.
Fournier-Massigan, Morgane, Girault, Jean-Marc, Kouamé, Denis, Voicu, Iulian   +3 more
core   +1 more source

Making stillbirths count, making numbers talk - issues in data collection for stillbirths. [PDF]

, 2009
BACKGROUND: Stillbirths need to count. They constitute the majority of the world's perinatal deaths and yet, they are largely invisible. Simply counting stillbirths is only the first step in analysis and prevention.
Abdel-Aleem, Hany, Bergsjø, Per, Betran, Ana, Duke, Charles W, Fauveau, Vincent, Flenady, Vicki, Frøen, J Frederik, Gordijn, Sanne J, Hinderaker, Sven Gudmund, Hofmeyr, G Justus, Jokhio, Abdul Hakeem, Lawn, Joy, Lumbiganon, Pisake, Merialdi, Mario, Pattinson, Robert, Shankar, Anuraj   +15 more
core   +6 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Evaluation of fetal wellbeing by antepartum fetal heart monitoring. [PDF]

, 1977
Anna M. Flynn, John Kelly
openalex   +1 more source