Results 111 to 120 of about 1,852,080 (263)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

open access: yesAdvanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin   +8 more
wiley   +1 more source

The effects of shocks in early life mortality on later life expectancy and mortality compression: A cohort analysis [PDF]

open access: yes
I study how shocks in cohort-level early life conditions, as represented by deviations from trend in mortality before age 5, affect later mortality. I use data for six European countries and find that shocks that increase infant mortality decrease later ...
Mikko Myrskylä
core  

A review of congenital heart block [PDF]

open access: yes, 2003
Congenital heart block is a rare disorder. It has an incidence of about 1 in 22,000 live births. It may be associated with high mortality and morbidity.
Glickstein, J.   +3 more
core  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Management of cardiopulmonary bypass in pregnancy: challenges and progress in maternal-fetal protection

open access: yesFrontiers in Cardiovascular Medicine
Maternal heart disease is a leading cause of maternal mortality, and the number of pregnant women requiring cardiac surgery has steadily increased despite advancements in diagnostic and therapeutic modalities.
Ziyuan Dong   +8 more
doaj   +1 more source

Fetal mortality in the United States : trends from 2014 through 2019 and changes between 2018\u20132019 and 2019\u20132020

open access: yes
https://www.cdc.gov/nchs/data/vsrr/VSRR018.pdfObjectives\u2014This report describes trends from 2014 through 2019 and changes between 2019 and 2020 for total, early, and late fetal mortality in the United States.

core  

The Determinants of Mortality [PDF]

open access: yes
Mortality rates have fallen dramatically over time, starting in a few countries in the 18th century, and continuing to fall today. In just the past century, life expectancy has increased by over 30 years.
Adriana Lleras-Muney   +2 more
core  

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

open access: yesAdvanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang   +8 more
wiley   +1 more source

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