Results 51 to 60 of about 329,411 (267)

Case Report: Primary cardiac synovial sarcoma invading the tricuspid valve in a pregnant woman

Frontiers in Cardiovascular Medicine
Primary cardiac synovial sarcoma (PCSS) is a rare and highly aggressive tumor with a significant mortality rate. Treatment guidelines have not been defined given the relative rarity of the condition, especially for pregnant women.
Mixia Li, Maoxun Huang, Hulin Piao, Yong Wang, Kexiang Liu   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Management of Severe Mitral Stenosis and Intrahepatic Cholestasis in a Pregnant Woman: A Case Report on Achieving Favorable Maternal and Neonatal Outcomes

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Mitral stenosis (MS) and intrahepatic cholestasis of pregnancy (IHCP) are two distinct and complex conditions that can significantly complicate pregnancy, leading to increased maternal and fetal morbidity and mortality. While MS primarily affects cardiac
Jayshree Kulkarni, Sneha Prasad, R Heena Vaswani, Apporva Dhankar, Poonam Nikam   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hubungan Preeklamsi Berat dengan Hasil Luaran Janin (Fetal Outcome) di RSUD Al-Ihsan Kabupaten Bandung

Global Medical & Health Communication, 2015
Abstrak Preeklamsi merupakan salah satu penyebab morbiditas dan mortalitas pada ibu dan neonatus. Beberapa keadaan hasil luaran janin pada ibu preeklamsi di antaranya small for gestasional age (SGA), asifiksia, prematuritas, dan stillbirth.
Dave Orlando Gumay, Hidayat Wijayanegara, - Zulmansyah   +2 more
doaj  

The Pathophysiology of Wharton’s Jelly and Its Impact on Fetal and Neonatal Outcomes: A Comprehensive Literature Review

Medical Sciences
Wharton’s jelly (WJ), the mucoid connective tissue of the umbilical cord, provides essential protection to the umbilical vessels against mechanical stress.
Tudor-Andrei Butureanu
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Treating without guidelines: management and outcomes of lung cancer diagnosed during pregnancy — a systematic review

Frontiers in Oncology
BackgroundLung cancer during pregnancy is exceedingly rare and poses unique diagnostic and therapeutic challenges. Clinical decisions must balance urgent, potentially lifesaving maternal treatment with fetal safety, often in the absence of evidence-based
Nehemias Guevara Rodriguez, Noemy Coreas, Coral Olazagasti, Martina Imbimbo, Narjust Florez   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Association Between Maternal Lactate Dehydrogenase Levels and Fetal Outcomes in Preeclampsia with Severe Features

Obgynia
Objective: To assess the association between maternal serum lactate dehydrogenase (LDH) levels and fetal outcomes in patients with preeclampsia with severe features.
Nurul Robiah Aladawiyah, Arissa Reissa Utami, Dalri Muhammad Suhartomo   +2 more
doaj   +1 more source