Results 61 to 70 of about 3,706,561 (264)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years [PDF]

, 2012
The authors performed a randomised trial in very preterm small-for-gestational age (SGA) babies to determine if prophylaxis with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial).
Carr, R., Robert Carr, Caroline Dore, Redshaw, ME, Petrou, Stavros, Marlow, N, Cowan, Frances M, Marlow, Neil, Nishma Patel, Neil Marlow, Timothy Morris, Dore, C., Carr, Robert, Maggie E Redshaw, Redshaw, M. E., Brocklehurst, P., Modi, N., Redshaw, Margaret, Redshaw, Maggie E., Patel, N., Morris, T., Peter Brocklehurst, Petrou, S, Stavros Petrou, Carr, R, Modi, Neena, Modi, N, Brocklehurst, Peter, Cowan, FM, Patel, Nishma, Morris, Timothy, Neena Modi, Morris, T, Dore, C, Frances M Cowan, Brocklehurst, P, Cowan, F. M., Cowan, Frances M., Patel, N, Dore, Caroline   +39 more
core   +1 more source

The association between narcolepsy during pregnancy and maternal-fetal risk factors/outcomes

, 2022
OBJECTIVE: We sought to determine whether narcolepsy in pregnancy is associated with adverse maternal-fetal outcomes. MATERIAL AND METHODS: A retrospective, cross-sectional analysis was performed using the nationwide inpatient sample (NIS) for the period
Marroquin, Maricarmen, Wilson, Annise, Annise Wilson, Maricarmen Marroquin, Salihu, Hamisu M, Hamisu M. Salihu, Krystal Carter, Carter, Krystal, Deepa Dongarwar, Dongarwar, Deepa   +9 more
core   +1 more source

Development of Fetal Yawn Compared with Non-Yawn Mouth Openings from 24-36 Weeks Gestation [PDF]

, 2012
Background: Although some research suggests that fetuses yawn, others disagree arguing that is it simple mouth opening. Furthermore there is no developmental account of fetal yawning compared with simple mouth opening. The aim of the present study was to
Francis, Brian, Mason, James, Reissland, Nadja   +2 more
core   +4 more sources

Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications

Biomedicines
Background: Dyslipidemia in pregnancy presents unique clinical challenges due to its effects on maternal and fetal health. This systematic review hypothesizes that molecular alterations in lipid metabolism during pregnancy contribute to adverse pregnancy
Agnesa Preda, Silviu-Daniel Preda, Maria Mota, Dominic Gabriel Iliescu, Lucian George Zorila, Alexandru Cristian Comanescu, Adina Mitrea, Diana Clenciu, Eugen Mota, Ionela Mihaela Vladu   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Pregnancy outcome of patients with Diabetes at University of Maiduguri Teaching Hospital: a 5-year retrospective review

Kanem Journal of Medical Sciences
Background: Diabetes Mellitus (DM) is a common medical disorder that complicates about 16% of pregnancies worldwide. DM may result in significant adverse maternal and fetal outcomes, if not recognised early and properly managed.
Ado D. Geidam, Rabiu Adams
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Evaluation of a novel assay for detection of the fetal marker RASSF1A: facilitating improved diagnostic reliability of noninvasive prenatal diagnosis [PDF]

, 2012
BackgroundAnalysis of cell free fetal (cff) DNA in maternal plasma is used routinely for non invasive prenatal diagnosis (NIPD) of fetal sex determination, fetal rhesus D status and some single gene disorders.
Carolyn L. Dent (135429), Oudejans, Cees, White, Helen E., Hall, Victoria J., Chitty, LS, Carolyn L Dent, John A. Crolla (135433), Lyn S. Chitty (135435), Dent, CL, Victoria J. Hall (135431), John A Crolla, White Helen E., Helen E. White (135428), Crolla, John A., Crolla, JA, Hall, VJ, Dent Carolyn L., Hall Victoria J., Chitty, Lyn S., Chitty Lyn S., Helen E White, Dent, Carolyn L., White, HE, Crolla John A., Lyn S Chitty, Victoria J Hall   +25 more
core   +1 more source