Results 61 to 70 of about 560,992 (241)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Case Report: Primary cardiac synovial sarcoma invading the tricuspid valve in a pregnant woman
Frontiers in Cardiovascular MedicinePrimary cardiac synovial sarcoma (PCSS) is a rare and highly aggressive tumor with a significant mortality rate. Treatment guidelines have not been defined given the relative rarity of the condition, especially for pregnant women.
Mixia Li +4 more
doaj +1 more source
Adverse Effects of Trichothiodystrophy DNA Repair and Transcription Gene Abnormalities on Human Fetal Development [PDF]
, 2009 The effects of DNA repair and transcription genes in human prenatal life have never been studied. Trichothiodystrophy (TTD) is a rare (affected frequency of 10^-6^) recessive disorder caused by mutations in genes involved in the nucleotide excision ...
Amiran Dzutsev +4 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Medical Journal of Dr. D.Y. Patil VidyapeethMitral stenosis (MS) and intrahepatic cholestasis of pregnancy (IHCP) are two distinct and complex conditions that can significantly complicate pregnancy, leading to increased maternal and fetal morbidity and mortality. While MS primarily affects cardiac
Jayshree Kulkarni +4 more
doaj +1 more source
Environmental contaminants exposure and preterm birth: a systematic review [PDF]
, 2019 Preterm birth is an obstetric condition associated with a high risk of infant mortality and morbidities in both the neonatal period and later in life, which has also a significant public health impact because it carries an important societal economic ...
Benedetti Panici, Pierluigi +5 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Global Medical & Health Communication, 2015 Abstrak Preeklamsi merupakan salah satu penyebab morbiditas dan mortalitas pada ibu dan neonatus. Beberapa keadaan hasil luaran janin pada ibu preeklamsi di antaranya small for gestasional age (SGA), asifiksia, prematuritas, dan stillbirth.
Dave Orlando Gumay +2 more
doaj
Medical SciencesWharton’s jelly (WJ), the mucoid connective tissue of the umbilical cord, provides essential protection to the umbilical vessels against mechanical stress.
Tudor-Andrei Butureanu
doaj +1 more source
A narrative review of interventions addressing the parental-fetal relationship [PDF]
, 2016 Background Expectant parents develop varying degrees of emotional affiliation with the unborn child. Interventions supporting this relationship may be beneficial given its link to maternal health behaviour during pregnancy, as well as the parental–infant
Borg Cunen, Nicole +4 more
core +1 more source