Results 81 to 90 of about 90,146 (293)
High Fat Programming and Cardiovascular Disease
Medicina, 2018 Programming is triggered through events during critical developmental phases that alter offspring health outcomes. High fat programming is defined as the maintenance on a high fat diet during fetal and/or early postnatal life that induces metabolic and ...
Marlon E. Cerf
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
EFFECTS OF INTRAUTERINE NUTRITION ON FETAL PROGRAMMING OF REPRODUCTIVE ORGANS AND THE FUTURE REPRODUCTIVE PERFORMANCE IN SHEEP [PDF]
SPERMOVA, 2015 The effects of uterine undernutrition during the embryonic and fetal development has been of concern in human medicine due to the consequences on the health and welfare of the people it causes.
Pérez-Clariget R, Bielli A
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Placental DEPTOR as a stress sensor during pregnancy [PDF]
, 2011 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Gidron, Y +4 more
core +2 more sources
Decoding Apelin: Its Role in Metabolic Programming, Fetal Growth, and Gestational Complications
ChildrenPlacental insufficiency and gestational diabetes, which are both serious pregnancy complications, are linked to altered fetal growth, whether restricted or excessive, and result in metabolic dysfunction, hypoxic/oxidative injury, and adverse perinatal ...
Nikolaos Loukas +11 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Fetal programming by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not ...
Gabriela Cruz-Carrillo +13 more
doaj +1 more source
Fetal programming and gestational diabetes mellitus [PDF]
Placenta, 2016 Gestational diabetes mellitus is defined by new-onset glucose intolerance during pregnancy. About 2-5% of all pregnant women develop gestational diabetes during their pregnancies and the prevalence has increased considerably during the last decade.
Monteiro, Lara J +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Lactation and neonatal nutrition: defining and refining the critical questions. [PDF]
, 2012 This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012.
Ardythe L. Morrow +37 more
core +2 more sources