Results 61 to 70 of about 90,146 (293)
Fetal programming of glucose–insulin metabolism [PDF]
Molecular and Cellular Endocrinology, 2009 Epidemiological studies have shown a link between poor fetal growth and increased risk of developing type 2 diabetes. These observations are highly reproducible in many populations worldwide although the mechanisms behind them remain elusive. The 'Thrifty Phenotype Hypothesis' was proposed to explain the underlying causes of these relationships. Animal
Jones, R Huw, Ozanne, Susan E
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Fetal Programming in Rheumatoid Arthritis [PDF]
, 2013 __Abstract__ Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease mainly affecting synovial tissues, which can lead to severe morbidity and progressive joint destruction resulting in deformations and disability.
Steenwinkel, F.D.O. (Florentien) de
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Fetal programming and future disease [PDF]
Revista do Hospital das Clínicas, 2004 Recent epidemiological studies have demonstrated a close relationship between low birth weight and a high predisposition to arterial hypertension, hyperlipidemia and non-insulin-dependent diabetes in adulthood. These findings may coexist as Syndrome X, more recently named as Metabolic Syndrome, and understood as precursory of coronary heart disease and
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
‘This growing genetic disaster’: obesogenic mothers, the obesity ‘epidemic’ and the persistence of eugenics [PDF]
, 2013 In this era of ever-increasing emphasis on personal responsibility the 'obesity epidemic', officialised in global health warnings, threatens to swamp the West with the consequences of overindulgence.
Cain, Ruth
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Fetal programming of the metabolic syndrome
Taiwanese Journal of Obstetrics & Gynecology, 2017 Prenatal development is currently recognized as a critical period in the etiology of human diseases. This is particularly so when an unfavorable environment interacts with a genetic predisposition.
Aleksandra Marciniak +5 more
doaj +1 more source
Frontiers in Nutrition, 2021 Diabetes has become the most common metabolic disease around the world. In addition to genetic and environmental factors in adulthood, the early life environment is critical to the progression of diabetes in adults, especially the environment during the ...
Yifan Wu, Qian Zhang, Xinhua Xiao
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Fetal Programming of Stress Responses
Stress, 2001 Epidemiological studies have shown that small size at birth is associated with an increased risk of coronary heart disease and its risk factors, including hypertension and Type 2 diabetes.It is suggested that these observations linking low birthweight with disease result from an imbalance between fetal nutrient demand and supply. This imbalance results
Ward, A.M.W., Phillips, D.I.W.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source