Results 151 to 160 of about 2,560,680 (304)

Functional expression of TRPV6 in human syncytiotrophoblasts from trophoblast stem cells - possible role in maternal-fetal calcium transport. [PDF]

J Physiol Sci
Suzuki Y, Otani S, Shibasaki S, Otsu K, Nakajima K.   +4 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Cloning of human DING: Developmental expression and downregulation by EtOH in-utero. [PDF]

Arch Intern Med Res
Darbinian N, Darbinyan A, Thin TH, Merabova N, Tatevosian-Geller T, Goetzl L, Simm M, Chabriere E, Amini S, Selzer ME.   +9 more
europepmc   +1 more source

TRANSPORT OF PROTEINS ACROSS THE FETAL MEMBRANES

Cold Spring Harbor Symposia on Quantitative Biology, 1954
openaire   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Machine learning-driven decoding of maternal immune signatures in repeated pregnancy loss. [PDF]

PLoS Comput Biol
Ko TL, Park J, Leem D, Kim J, Han JW, Park JS, Lee SK, Paik H.   +7 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

IMP1 is a novel posttranscriptional regulator of early erythroid development and embryonic globin output. [PDF]

Blood Adv
MacInnes KA, Ferrer-Vicens I, Hancock M, Trakarnsanga K, Daniels DE, Wilson MC, Frayne J.   +6 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Warfarin-Induced Developmental Toxicity: Insights into Embryogenesis, Teratogenicity, and Molecular Pathways. [PDF]

J Dev Biol
Magee E, Kuhnel G, Geetha-Loganathan P.
europepmc   +1 more source