Results 91 to 100 of about 264,292 (256)

Iatrogenic gastroschisis in an ovine model of left-sided congenital diaphragmatic hernia

The Journal of Maternal-Fetal & Neonatal Medicine
Objective To assess the effect of an iatrogenic gastroschisis on fetal pulmonary growth in an animal model of congenital left-sided diaphragmatic hernia (CDH).Methods Eighteen time-dated ewes were studied: Group I: healthy controls (H); Group II: CDH ...
Ruben Quintero, Carlos Ramos, Marcelo Vega, Mikaela Bulman, Alejandro Rizk, Natalia D’Alessio, Juan Giacosa, Gabriel Iorio, Josefina Sala, Thora Steffensen, Eftichia Kontopoulos   +10 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Minimally Invasive Bimanual Fetal Surgery-A Review. [PDF]

Children (Basel), 2022
Brunner SE, Durmaz LO, Meinzer A, Arp M, Krebs TF, Bergholz R.   +5 more
europepmc   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Tolerância da placenta à parada circulatória umbilical normotérmica Tolerance of placenta to normothermic umbilical circulatory arrest

Brazilian Journal of Cardiovascular Surgery, 1992
O aumento da resistência vascular placentáriae distúrbios de trocas gasosas freqüentemente ocorrem após a circulação extracorpórea (CEC) fetal. A utilização de um circuito convencional de CEC que exclua a placenta da circulação através do clampeamento ...
Renato S Assad, Fan-Yen Lee, Joseph Sabik, Saralyn Mackenzie, Frank L Hanley   +4 more
doaj  

Longitudinal MRI in the context of in utero surgery for open spina bifida: A descriptive study

Acta Obstetricia et Gynecologica Scandinavica
Introduction Fetal surgery for open spina bifida (OSB) requires comprehensive preoperative assessment using imaging for appropriate patient selection and to evaluate postoperative efficacy and complications.
Nada Mufti, Michael Aertsen, Dominic Thomson, Phillippe De Vloo, Philippe Demaerel, Jan Deprest, Andrew Melbourne, Anna L. David, the GIFT‐Surg Imaging Working Group   +8 more
doaj   +1 more source

Fetal surgery is not associated with increased inflammatory placental pathology. [PDF]

Prenat Diagn, 2023
Cardenas MC, Cheek-Norgan EH, Branda ME, Norgan AP, Schenone MH, Lemens MA, Chakraborty R, Ruano R, Enninga EAL.   +8 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Bloqueio AV total congênito: novo modelo experimental para avaliação do marcapasso fetal Fetal heart block: a new experimental model to assess fetal pacing

Brazilian Journal of Cardiovascular Surgery, 1994
O implante de marcapasso epicárdíco em fetos via toracotomia é um procedimento potencialmente mais seguro e eficaz para se tratar o bloqueio AV total congênito (BAVT), quando associado à hidropsia fetal e refratário ao tratamento clínico. Este estudo foi
Renato S Assad, Marcelo B Jatene, Luiz Felipe P Moreira, Paulo C Sales, Vera Demarqui Aiello, Roberto Costa, Frank L Hanley, Adib D Jatene   +7 more
doaj  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source