Results 71 to 80 of about 3,436,268 (369)

Decreasing trend of gastroschisis prevalence in the United States from 2014 through 2022: Is attributed to declining birth rates in young, high-risk gravidae

European Journal of Obstetrics & Gynecology and Reproductive Biology: X
Objectives: To investigate the prevalence trend of gastroschisis in the United States between 2014 and 2022. Methods: A cross-sectional retrospective analysis of the Centers for the United States live births between 2014 and 2022.
Hiba J. Mustafa, Nikan Zargarzadeh, Kevin L. Moss, May Abiad, Brian Gray, Kjersti M. Aagaard, Terry L. Buchmiller, Erin E. Perrone, Alireza A. Shamshirsaz   +8 more
doaj   +1 more source

Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.

Neurosurgical Focus, 2019
OBJECTIVE Comparing prenatal and postnatal surgical repair techniques for myelomeningocele (MMC), in utero fetal surgery has increasingly gained acceptance and is considered by many specialized centers the first choice of treatment. Despite its benefits,
M. Licci, R. Guzman, Jehuda Soleman
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Enhanced Recovery After Surgery for Pediatric Lung Resection: Effects of a New Protocol

Children
Background: Prenatal detection of congenital lung lesions has increased with improved imaging. These abnormalities are safely treated with thoracoscopic lobectomy.
Andrew J. Behrmann, Elizabeth A. Shumway, Brooklyn Campbell, Cannon Dew, Tara Kempker, Jessica Peuterbaugh, Venkataraman Ramachandran, Yousef El-Gohary, Ahmed I. Marwan   +8 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Maternal outcomes following prenatal spina bifida repair: A systematic review and meta‐analysis

Pregnancy
Objective Prenatal surgical interventions for neural tube defects have been shown to improve fetal outcomes but are associated with previously poorly quantified maternal risk, which is inherently dependent on the surgical approach used.
Nikan Zargarzadeh, Ehsan Rojhani, Ali Javinani, May Abiad, Enaja Sambatur, Eyal Krispin, Ashish Premkumar, Ramen H. Chmait, Ramesha Papanna, Jena Lyn Miller, Kjersti Aagaard, Alireza A. Shamshirsaz   +11 more
doaj   +1 more source

Spina Bifida: A Review of the Genetics, Pathophysiology and Emerging Cellular Therapies

Journal of Developmental Biology, 2022
Spina bifida is the most common congenital defect of the central nervous system which can portend lifelong disability to those afflicted. While the complete underpinnings of this disease are yet to be fully understood, there have been great advances in ...
Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang, Diana Lee Farmer   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Spinal cord untethering after fetal myelomeningocele repair

Archives of Pediatric Neurosurgery, 2021
The incidence of tethered cord syndrome after myelomenigocele (MMC) repair is higher in patients undergoing in utero than postnatally. However, a paucity of studies have described the details of untethering in children which MMC was corrected during ...
Leopoldo Mandic Furtado, José Aloysio da Costa Val Vilho, José Antônio Lima Vieira, Aieska Kellen Dantas dos Santos   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source